Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
Autore:
Sugiyama, F; Churchill, GA; Higgins, DC; Johns, C; Makaritsis, KP; Gavras, H; Paigen, B;
Indirizzi:
Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA Boston Univ, Sch Med, Hypertens Sect, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 Med, Hypertens Sect, Boston, MA 02118 USA
Titolo Testata:
GENOMICS
fascicolo: 1, volume: 71, anno: 2001,
pagine: 70 - 77
SICI:
0888-7543(20010101)71:1<70:COMQTL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE QTL; SENSITIVE HYPERTENSION; LINKAGE ANALYSIS; CONGENIC STRAIN; GENOME SCAN; MICE; GENES; SYSTEM; RENIN; CONSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Churchill, GA Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA Jackson Lab 600 Main St Bar Harbor ME USA 04609 ME 04609 USA
Citazione:
F. Sugiyama et al., "Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci", GENOMICS, 71(1), 2001, pp. 70-77

Abstract

To investigate the genetic control of salt-induced hypertension, we performed a quantitative trait locus analysis on male mice from a reciprocal backcross between the salt-sensitive C57BL/6J and the normotensive A/J inbred mouse strains after they were provided with water containing 1% salt for 2 weeks. Genome-wide scans performed on these mice and analyzed with a combination of conventional marker-based regressions and a novel simultaneous search for pairs revealed six significant quantitative trait loci associated with salt-induced blood pressure, two of which were interacting loci. These six loci, named Bpq1-6 for blood pressure quantitative trait loci, mapped toD1Mit334, D1Mit14, D4Mit164, D5Mit31, D6Mit15, and D15Mit13. Furthermore, five of these six loci were concordant with hypertension loci in rats, and four were concordant with hypertension loci in humans, suggesting that quantitative trait loci mapping in model organisms can be used to guide the search for human blood pressure genes. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:05:15