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Titolo:
LACK OF INTERACTION BETWEEN TACROLIMUS (FK506) AND METHOTREXATE IN BONE-MARROW TRANSPLANT RECIPIENTS
Autore:
WINGARD JR; NASH RA; RATANATHARATHORN V; FAY JW; KLEIN JL; PRZEPIORKA D; MAHER RM; DEVINE SM; BOSWELL G; BEKERSKY I; FITZSIMMONS W;
Indirizzi:
UNIV FLORIDA,COLL MED,JHMHC,DEPT MED,DIV HEMATOL ONCOL,BONE MARROW TRANSPLANT PROGRAM,POB 100277 GAINESVILLE FL 32610 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104 UNIV MICHIGAN ANN ARBOR MI 48109 BAYLOR UNIV,MED CTR DALLAS TX 00000 WAYNE STATE UNIV DETROIT MI 00000 UNIV TEXAS,MD ANDERSON CANCER CTR HOUSTON TX 77030 FUJISAWA USA DEERFIELD IL 00000 LUTHERAN GEN HOSP CHICAGO IL 00000
Titolo Testata:
Bone marrow transplantation
fascicolo: 1, volume: 20, anno: 1997,
pagine: 49 - 51
SICI:
0268-3369(1997)20:1<49:LOIBT(>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE;
Keywords:
TACROLIMUS; METHOTREXATE; GRAFT-VERSUS-HOST DISEASE; FK506;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Wingard et al., "LACK OF INTERACTION BETWEEN TACROLIMUS (FK506) AND METHOTREXATE IN BONE-MARROW TRANSPLANT RECIPIENTS", Bone marrow transplantation, 20(1), 1997, pp. 49-51

Abstract

Tacrolimus (FK506) is a macrolide lactone effective in the control ofgraft-versus-host disease (GVHD). An interaction between high-dose methotrexate and a macrolide antibiotic (pristinamycin) leading to prolonged methotrexate exposure has been described, Because a randomized prospective trial comparing tacrolimus with cyclosporine (both in combination with methotrexate) following allogeneic BMT showed the tacrolimus plus methotrexate regimen to be more effective in prevention of GVHD, we assessed methotrexate pharmacokinetics in a subgroup of the participants of this trial to evaluate the possibility that an interaction of FK506 and methotrexate was the explanation for the clinical findings. Mean and median methotrexate levels at various time-points after the day 1 and 6 methotrexate doses were comparable in the tacrolimus andcyclosporine cohorts and were elevated in only three of 70 study patients. Area under the curve (AUC) concentrations were also similar after the day 1 and 6 methotrexate doses, Thus, no significant interactionbetween tacrolimus and methotrexate is apparent and the differences in efficacy between tacrolimus and cyclosporine are unlikely to be attributable to pharmacologic interactions with methotrexate.

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Documento generato il 03/07/20 alle ore 00:22:51