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Titolo:
Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation
Autore:
Fluker, M; Grifo, J; Leader, A; Levy, M; Meldrum, D; Muasher, SJ; Rinehart, J; Rosenwaks, Z; Scott, RT; Schoolcraft, W; Shapiro, DB;
Indirizzi:
Genesis Fertil Ctr, Vancouver, BC, Canada Genesis Fertil Ctr Vancouver BCCanada Fertil Ctr, Vancouver, BC, Canada NYU, Med Ctr, Program In Vitro Fertilizat Reprod Surg & Infe, New York, NY10016 USA NYU New York NY USA 10016 lizat Reprod Surg & Infe, New York, NY10016 USA Fertil Ctr, Ottawa, ON, Canada Fertil Ctr Ottawa ON CanadaFertil Ctr, Ottawa, ON, Canada Shady Grove Fertil Ctr, Rockville, MD USA Shady Grove Fertil Ctr Rockville MD USA ve Fertil Ctr, Rockville, MD USA Reprod Partners Med Grp, Redondo Beach, CA USA Reprod Partners Med Grp Redondo Beach CA USA Grp, Redondo Beach, CA USA Jones Inst Womens Hlth, Norfolk, VA USA Jones Inst Womens Hlth Norfolk VAUSA Inst Womens Hlth, Norfolk, VA USA Ctr Human Reprod, Glenview, IL USA Ctr Human Reprod Glenview IL USACtr Human Reprod, Glenview, IL USA Cornell Med Ctr, New York, NY USA Cornell Med Ctr New York NY USACornell Med Ctr, New York, NY USA Reprod Med Assoc New Jersey, Morristown, NJ USA Reprod Med Assoc New Jersey Morristown NJ USA Jersey, Morristown, NJ USA Reprod Biol Assoc, Atlanta, GA USA Reprod Biol Assoc Atlanta GA USAReprod Biol Assoc, Atlanta, GA USA Ctr Reprod Med, Englewood, CO USA Ctr Reprod Med Englewood CO USACtr Reprod Med, Englewood, CO USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 75, anno: 2001,
pagine: 38 - 45
SICI:
0015-0282(200101)75:1<38:EASOGA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY FEMALE VOLUNTEERS; PHARMACODYNAMIC CHARACTERISTICS; ANTAGON/ORGALUTRAN-ASTERISK; STIMULATION; FERTILIZATION; SUPPRESSION; INDUCTION; AGONISTS; ANALOGS; IVF;
Keywords:
in vitro fertilization; infertility; controlled ovarian hyperstimulation; ganirelix acetate; Antagon; leuprolide acetate; fertilization; oocyte; implantation rate; pregnancy rate; embryo quality; open-label;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Fluker, M Organon Inc, Med Serv, 375 Mt Pleasant, W Orange, NJ 07052 USA Organon Inc 375 Mt Pleasant W Orange NJ USA 07052 , NJ 07052 USA
Citazione:
M. Fluker et al., "Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation", FERT STERIL, 75(1), 2001, pp. 38-45

Abstract

Objective: To assess the efficacy, safety, and local tolerance of ganirelix acetate for the inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation (COH). Design: Phase III, multicenter, open-label randomized trial. Setting: In vitro fertilization (IVF) centers in North America. Patient(s): Healthy female partners (n = 313) in subfertile couples for whom COH and IVF or intracytoplasmic sperm injection were indicated. Intervention(s): Patients were randomized to receive one COH cycle with ganirelix or the reference treatment, a long protocol of leuprolide acetate in conjunction with follitropin-beta for injection. Outcome Measure(s): Number of oocytes retrieved, pregnancy rates, endocrine variables, and safety variables. Result(s): The mean number of oocytes retrieved per attempt was 11.6 in the ganirelix group and 14.1 in the leuprolide group. Fertilization rates were 62.4% and 61.9% in the ganirelix and leuprolide groups, respectively, andimplantation rates were 21.1% and 26.1%. Clinical and ongoing pregnancy rates per attempt were 35.4% and 30.8% in the ganirelix group and 38.4% and 36.4% in the leuprolide acetate group. Fewer moderate and severe injection site reactions were reported with ganirelix (11.9% and 0.6%) than with leuprolide (24.4% and 1.1%). Conclusion(s): Ganirelix is effective, safe, and well tolerated. Compared with leuprolide acetate, ganirelix therapy has a shorter duration and fewerinjections but produces a similar pregnancy rate. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:05:06