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Titolo:
Immunobiology of endometriosis
Autore:
Lebovic, DI; Mueller, MD; Taylor, RN;
Indirizzi:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Michigan, Dept Obstet & Gynecol, Div Reprod Endocrinol, Ann Arbor, MI48109 USA Univ Michigan Ann Arbor MI USA 48109 d Endocrinol, Ann Arbor, MI48109 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 75, anno: 2001,
pagine: 1 - 10
SICI:
0015-0282(200101)75:1<1:IOE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; IN-VITRO FERTILIZATION; MACROPHAGE-CONDITIONED MEDIA; MESSENGER-RIBONUCLEIC-ACID; PERITONEAL-FLUID; STROMAL CELLS; FACTOR-ALPHA; TNF-ALPHA; INFERTILE WOMEN;
Keywords:
endometriosis; endometrium; cytokines; chemokines; angiogenesis; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, RN Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, CtrReprod Sci, HSE 1689,Box 0556, San Francisco, CA 94143 USA Univ Calif San Francisco HSE 1689,Box 0556 San Francisco CA USA 94143
Citazione:
D.I. Lebovic et al., "Immunobiology of endometriosis", FERT STERIL, 75(1), 2001, pp. 1-10

Abstract

Objective: To provide a review of the humoral and cellular immunology of endometriosis and to discuss the rationale for future approaches to diagnosis and treatment. Design: Literature survey. Result(s): Defective immunosurveillance in women who are destined to develop endometriosis may allow for the survival of ectopic endometrial tissue. The evidence includes endometrial cell resistance to apoptosis, perhaps through the secretion of proteins that interfere with implant recognition and/or FasL expression by stromal cells, inducing apoptosis of Fas-bearing immune cells. Although the immune response may be defective, aspects of it clearly are enhanced in endometriosis, as is seen by the generalized polyclonalB-cell autoimmune activation and secretion of immune proteins. Several cytokines, chemokines, and growth factors (including vascular growth factors) are increased in women with endometriosis. Conclusion(s): A complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. Proinflammatory proteins from endometriotic lesions-and associated immune cells contribute to the enhanced inflammatory reaction associated with endometriosis that subserves the survival of these lesions instead of leading to their demise. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 02:47:37