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Titolo:
TGF-alpha mRNA expression in renal organogenesis: A study in rat and humanembryos
Autore:
Bernardini, N; Mattii, L; Bianchi, F; Da Prato, I; Dolfi, A;
Indirizzi:
Univ Pisa, Fac Med & Surg, Dept Human Morphol & Appl Biol, Sect Histol & Gen Embryol, I-56126 Pisa, Italy Univ Pisa Pisa Italy I-56126 t Histol & Gen Embryol, I-56126 Pisa, Italy
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 2, volume: 9, anno: 2001,
pagine: 90 - 98
SICI:
1018-7782(200103/04)9:2<90:TMEIRO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; DEVELOPMENTAL EXPRESSION; KIDNEY DEVELOPMENT; MOUSE DEVELOPMENT; FACTOR RECEPTOR; MESSENGER-RNA; LOCALIZATION; ONTOGENY; MESONEPHROS; TISSUES;
Keywords:
transforming growth factor-alpha; in situ hybridization; kidney, embryonic; rat kidney; human kidney;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Dolfi, A Univ Pisa, Fac Med & Surg, Dept Human Morphol & Appl Biol, Sect Histol & Gen Embryol, Via Roma 55, I-56126 Pisa, Italy Univ Pisa Via Roma 55Pisa Italy I-56126 55, I-56126 Pisa, Italy
Citazione:
N. Bernardini et al., "TGF-alpha mRNA expression in renal organogenesis: A study in rat and humanembryos", EXP NEPHROL, 9(2), 2001, pp. 90-98

Abstract

The peptides belonging to the epidermal growth factor (EGF) family play a significant role in kidney development by binding the EGF receptor. Transforming growth factor-alpha (TGF alpha), a member of this family, is thought to be the fetal ligand of the EGF receptor. The present study aims to localize the TGF alpha transcripts in rat and human embryonic kidneys using a nonradioactive in situ hybridization method on paraffin-embedded embryonic samples. The results obtained in this study, beside demonstrating the usefulness of the nonradioactive technique for the detection of TGF alpha mRNA in paraffin sections, allowed TGF alpha -producing cells to be seen in developing kidneys. TGF alpha mRNA and its respective peptide were found in the primitive mesonephric structures and within metanephric blastema and uretericbud cells. The presence of the TGF alpha gene transcript in the developingrat and human kidney suggests that the TGF alpha peptide is of embryonic origin and that it may contribute to renal organogenetic processes together with other growth factors. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:12:40