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Titolo:
Effects of age and weaning on the immature rat uterotrophic assay using ethynylestradiol
Autore:
Yamasaki, K; Sawaki, M; Noda, S; Takatuki, M;
Indirizzi:
Chem Assessment Ctr, Chem Evaluat & Res Inst, Oita 0870061, Japan Chem Assessment Ctr Oita Japan 0870061 t & Res Inst, Oita 0870061, Japan
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 1, volume: 50, anno: 2001,
pagine: 87 - 89
SICI:
1341-1357(200101)50:1<87:EOAAWO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR; SENSITIVITY; EXPOSURE; BATTERY; GROWTH;
Keywords:
age; uterotrophic assay; weaning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Yamasaki, K Chem Assessment Ctr, Chem Evaluat & Res Inst, 3-822 Ishii, Oita 0870061, Japan Chem Assessment Ctr 3-822 Ishii Oita Japan 0870061 061, Japan
Citazione:
K. Yamasaki et al., "Effects of age and weaning on the immature rat uterotrophic assay using ethynylestradiol", EXP ANIM, 50(1), 2001, pp. 87-89

Abstract

The purpose of this study was to evaluate the most appropriate rat age forthe start of administration, and the effect of weaning, in the immature rat uterotrophic assay using ethynylestradiol (EE). Animals weaned on postnatal day (PND) 20 were administered subcutaneously EE at doses of 0.06-6 mug/kg/day for 3 days beginning on PND 21, 23 or 25. EE at the same doses was also administered to rats weaned on PND 17 or 20 from PND 21 for 3 days. Although uterine weight was significantly increased in the rats given 0.6-6 mug/kg EE in both of the studies, the percentage increase relative to the control in each group given EE from PND 21 and weaned on PND 20 was higher than in those groups given EE from PND 23 or 25, and the group weaned on PND 17.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:12:55