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Titolo:
Effect of M-2 and M-3 muscarinic receptors on airway responsiveness to carbachol in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs
Autore:
Kadota, H; Kuwahara, M; Nishibata, R; Mikami, H; Tsubone, H;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Comparat Pathophysiol, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 ophysiol, Bunkyo Ku, Tokyo 1138657, Japan Nippon Zoki Pharmaceut, Inst Bioact Sci, Kobe, Hyogo 6731461, Japan NipponZoki Pharmaceut Kobe Hyogo Japan 6731461 obe, Hyogo 6731461, Japan
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 1, volume: 50, anno: 2001,
pagine: 49 - 58
SICI:
1341-1357(200101)50:1<49:EOMAMM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RELEASE; ASTHMATIC SUBJECTS; 2 LINES; TRACHEA; CONTRACTION; INHIBITION; HYPERRESPONSIVENESS; HYPERREACTIVITY; POLYMORPHISMS; SENSITIVITY;
Keywords:
airway smooth muscle; carbachol; mRNA; muscarinic receptor subtypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kuwahara, M Univ Tokyo, Grad Sch Agr & Life Sci, Dept Comparat Pathophysiol, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1138657 kyo 1138657, Japan
Citazione:
H. Kadota et al., "Effect of M-2 and M-3 muscarinic receptors on airway responsiveness to carbachol in bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs", EXP ANIM, 50(1), 2001, pp. 49-58

Abstract

The expression balance of M-2 and M-3 muscarinic receptor subtypes on the pathogenesis of airway hyperresponsiveness was investigated by using two congenitally related strains of guinea pigs, bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR). CCh-induced airway responses in vivo and in vitro were investigated by comparing the effects of muscarinic receptor subtype antagonists, and the relative amounts of M-2 and M-3 muscarinic receptor mRNA in tracheal smooth muscle and lung tissue were investigated. After treatment with muscarinic receptor subtype antagonists, the ventilatory mechanics (V-T R-aw, and C-dyn) of response to CCh aerosol inhalation were measured by the bodyplethysmograph method. The effects of these antagonistson CCh-induced tracheal smooth muscle contraction were also investigated. The effects of M-2 muscarinic receptor blockade were less but the effects of M-3 muscarinic receptors blockade on the airway contractile responses were greater in BHS than in BHR. in M-3 muscarinic receptor blockades, CCh-induced tracheal contractions in BHS were significantly greater than those in BHR. In tracheal smooth muscle from BHS, the relative amount of M-2 muscarinic receptors mRNA was less but that of M-3 muscarinic receptor mRNA was more than those in BHR, These results suggest that the high ACh level as a consequence of dysfunction of M-2 muscarinic autoreceptors and the excessive effect of M-3 muscarinic receptors on the airway smooth muscle may play an important role in the pathogenesis of airway hyperresponsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:47:57