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Titolo:
Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer
Autore:
Funabashi, H; Uchida, K; Kado, S; Matsuoka, Y; Ohwaki, M;
Indirizzi:
Yakult Cent Inst Microbiol Res, Kunitachi, Tokyo 1868650, Japan Yakult Cent Inst Microbiol Res Kunitachi Tokyo Japan 1868650 68650, Japan
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 1, volume: 50, anno: 2001,
pagine: 41 - 47
SICI:
1341-1357(200101)50:1<41:EOATAT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; APC GENE; MICE; P53; MUTATIONS; TUMORS;
Keywords:
animal model; colorectal cancer; T-cell receptor beta chain (TCR beta); Transformation related protein 53 (p53);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Funabashi, H Yakult Cent Inst Microbiol Res, 1796 Yaho, Kunitachi, Tokyo 1868650, Japan Yakult Cent Inst Microbiol Res 1796 Yaho Kunitachi Tokyo Japan 1868650
Citazione:
H. Funabashi et al., "Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer", EXP ANIM, 50(1), 2001, pp. 41-47

Abstract

A congenic C57BL/6JJcl-Tcrb(tm1Mom)Trp53(tm1) (Tcrb(-/-): Trp53(-/-)) mouse lacking T-cell receptor beta chain (TCR beta) and transformation related protein 53 (p53) has been established at the N8th generation of backcrossing male Tcrb(-/-):Trp53(-/-) mice, which had been obtained by mating a Tcrb(-/-) mouse with a Trp53(-/-) mouse, with female C57BL/6JJcl mice, In the mice deficient for the both genes, occurrence of tumor masses was observed mostly in the cecum with high frequency as examined at 3 months of age. The majority of the masses had histologic features of hyperplasia or dysplasia while occasional lesions were noted to be adenocarcinomas invading the submucosa (invasive adenocarcinoma). As examined at 4 months of age and thereafter, ail mice had 4-5 colorectal tumors per animal, the lesions being located mainly in the cecum and, histopathologically, all the obvious neoplastic growths in the regions examined were invasive adenocarcinomas. The Tcrb andTrp53 genes deficient mouse strain which develops spontaneous colorectal carcinoma with fairly high frequency at early age would be useful as an animal model for colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:34:02