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Titolo:
Postrest contraction in the ventricular papillary muscle of spontaneously diabetic WBN/Kob rat
Autore:
Yamato, T; Yamasaki, S; Misumi, Y; Kino, M; Obata, T; Aomine, M;
Indirizzi:
Nakamura Gakuen Univ, Grad Sch Hlth & Nutr Sci, Div Nutr Physiol, Fukuoka 8140198, Japan Nakamura Gakuen Univ Fukuoka Japan 8140198 ysiol, Fukuoka 8140198, Japan Nakamura Gakuen Univ, Grad Sch Hlth & Nutr Sci, Div Food Proc, Fukuoka 8140198, Japan Nakamura Gakuen Univ Fukuoka Japan 8140198 Proc, Fukuoka 8140198, Japan Oita Med Univ, Dept Pharmacol, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 iv, Dept Pharmacol, Oita 8795593, Japan
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 1, volume: 50, anno: 2001,
pagine: 19 - 31
SICI:
1341-1357(200101)50:1<19:PCITVP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTION-POTENTIAL DURATION; RESTED-STATE CONTRACTION; SARCOPLASMIC-RETICULUM; COOLING CONTRACTURES; POTASSIUM CURRENTS; RABBIT VENTRICLE; CARDIAC-MUSCLE; CALCIUM; MYOCYTES; MECHANISM;
Keywords:
genetic diabetes mellitus; postrest contraction; SR dysfunction; ventricular muscle; WBN/Kob rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Aomine, M Nakamura Gakuen Univ, Grad Sch Hlth & Nutr Sci, Div Nutr Physiol, 5-7-1 Befu, Fukuoka 8140198, Japan Nakamura Gakuen Univ 5-7-1 Befu Fukuoka Japan 8140198 98, Japan
Citazione:
T. Yamato et al., "Postrest contraction in the ventricular papillary muscle of spontaneously diabetic WBN/Kob rat", EXP ANIM, 50(1), 2001, pp. 19-31

Abstract

In the present study, we investigated the characteristics of the postrest contraction (PRC) in chronic diabetic ventricular muscle. We used WBN/Kob rats of 7-8 weeks as the spontaneously diabetic animal and Wistar rats of 7-8 weeks as the control. We found: (1) No significant differences were seen in the amplitude, the contracting speed, and the relaxing speed of electrically stimulated twitch tension between control and WBN/Kob rats. In addition, the relationship between amplitude of twitch tension and stimulus cycle lengths (0.2-5 sec) was very similar in both animals. (2) The ratios of thefirst twitch tension (T-1) of PRC with various rest intervals (5-600 sec) to the steady-state tension (T-ss) were significantly smaller in the diabetic rats than in the controls. (3) When the preparation was stimulated at shorter cycle lengths, the recovery process of PRC was separated into at least two components (fast and slow components). In the diabetic rats, the timeconstant (tau) of both components was significantly longer than in controls. (4) After caffeine (10(-3) M) treatment, tau of the fast component in the control rats became longer, whereas it remained unchanged in diabetic rats. These findings suggest a dysfunction of the intracellular calcium handling system in spontaneously diabetic heart that is likely to include impaired calcium sequestration and/or extrusion.

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Documento generato il 30/03/20 alle ore 18:48:18