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Titolo:
Efficacy of rifampin-levofloxacin as a prophylactic agent in preventing Staphylococcus epidermidis graft infection
Autore:
Ghiselli, R; Giacometti, A; Goffi, L; Cirioni, O; Boccoli, G; Mocchegiani, F; Riva, A; Scalise, G; Saba, V;
Indirizzi:
Univ Ancona, IRRCS, INRCA, Dept Gen Surg, Ancona, Italy Univ Ancona Ancona Italy na, IRRCS, INRCA, Dept Gen Surg, Ancona, Italy Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy Univ Ancona Ancona Italy na, Inst Infect Dis & Publ Hlth, Ancona, Italy
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 6, volume: 20, anno: 2000,
pagine: 508 - 511
SICI:
1078-5884(200012)20:6<508:EORAAP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DACRON GRAFT; RESISTANCE; AUREUS; CIPROFLOXACIN; VANCOMYCIN;
Keywords:
vascular prostheses; contamination; bacteria; antibiotics; prophylaxis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Giacometti, A Azienda Osped Umberto 1, Clin Malattie Infett, Piazza Cappelli 1, I-60121 Ancona, Italy Azienda Osped Umberto 1 Piazza Cappelli 1 Ancona Italy I-60121
Citazione:
R. Ghiselli et al., "Efficacy of rifampin-levofloxacin as a prophylactic agent in preventing Staphylococcus epidermidis graft infection", EUR J VAS E, 20(6), 2000, pp. 508-511

Abstract

Objectives: to investigate the efficiency of levofloxacin in the prevention of vascular prosthetic fraft infection in a rat model. Methods: graft infections were established in the subcutaneous tissue of 225 male Wistar rats by implantation of Dacron prostheses followed by topical inoculation with methicillin-susceptible and methicillin-resistant S. epidermidis. The study included a group without contamination, two contaminated groups without prophylaxis, two contaminated groups with intraperitoneal levofloxacin prophylaxis, two contaminated groups with intraperitoneal cefazolin prophylaxis, two contaminated groups with intraperitoneal teicoplaninprophylaxis and six contaminated groups with rifampin-soaked graft and intraperitoneal levofloxacin, cefazolin or teicoplanin prophylaxis. The graftswere removed after 7 days and evaluated by quantitative culture. Results: the efficacy of levofloxacin against the methicillin-susceptible strain was not different to that of cefazolin or leicoplanin. Levofloxacin showed slight less efficicacy than teicoplanin against the methicillin-resistant strain. The combination levofloxacin-rifampin demonstrated to be similarly effective to the combination rifampin-teicoplanin and more effective than the combination rifampin-cefazolin against both strains. Conclusions: rifampin-levofloxacin combination seems useful for the prevention of late-appearing vascular graft infections caused by S. epidermidis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:10:03