Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Plasminogen activators, matrix metalloproteinases, and their inhibitors inimplanted vascular prostheses
Autore:
Urayama, H; Katada, S; Kasashima, F; Tanaka, Y; Kawasuji, K; Watanabe, Y;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 6, volume: 20, anno: 2000,
pagine: 501 - 507
SICI:
1078-5884(200012)20:6<501:PAMMAT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMAL HYPERPLASIA; AORTIC-ANEURYSM; LOCALIZATION; EXPRESSION; DACRON; GRAFTS;
Keywords:
vascular prosthesis; intimal hyperplasia; anastomotic aneurysm; matrix metalloproteinase; plasminogen activator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Urayama, H Kanazawa Univ, Sch Med, Dept Surg 1, 13-1 Takara Machi, Kanazawa, Ishikawa9208641, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa IshikawaJapan 9208641
Citazione:
H. Urayama et al., "Plasminogen activators, matrix metalloproteinases, and their inhibitors inimplanted vascular prostheses", EUR J VAS E, 20(6), 2000, pp. 501-507

Abstract

Objectives: to examine the role of plasminogen activators (PAs) and matrixmetalloproteinases (MMPs) in the healing of prosthetic grafts. Methods: thirty explanted grafts (26 Dacron and 24 DTFE) were studied immunohistochemically using antibodies to PAs, MMPs, and their inhibitors. The percentages of immunostain-positive multinucleated giant cells (MGC) were related to duration of implantation (early vs late), type of lesion (stenosis vs false aneurysm), graft material (Dacron vs PTFE), and graft status (occluded vs patent). Results: all specimens were positive for PAs and MMPs, There were no significant differences; in the percentages of MGCs positive for PAs, MMPs, or tissue inhibitor type 2 of MMP (TIMP-2) between the groups. The percentage of TIMP-1 in the aneurysm group (mean, 26%) was significantly lower than that of the stenosis group (mean, 46%) (p<0.05). Conclusion: after the implantation of a vascular prosthesis, PAs and MMPs are expressed in cell migration, proliferation and matrix construction. Under-expression of TIMP-1 may be related to the formulation of an anastomoticaneurysm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 14:42:34