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Titolo:
Monitoring of p53 autoantibodies after resection of colorectal cancer: Relationship to operative curability
Autore:
Takeda, A; Shimada, H; Nakajima, K; Imaseki, H; Suzuki, T; Asano, T; Ochiai, T; Isono, K;
Indirizzi:
Chiba Univ, Sch Med, Dept Surg 2, Chiba 280, Japan Chiba Univ Chiba Japan 280 Univ, Sch Med, Dept Surg 2, Chiba 280, Japan
Titolo Testata:
EUROPEAN JOURNAL OF SURGERY
fascicolo: 1, volume: 167, anno: 2001,
pagine: 50 - 53
SICI:
1102-4151(200101)167:1<50:MOPAAR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES; PROTEIN; CARCINOMA;
Keywords:
p53 autoantibodies; colorectal cancer; postoperative monitoring; operative curability; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, A Funabashi Municipal Med Ctr, Div Surg, 1-21-1 Kanasugi, Chiba 2738588, Japan Funabashi Municipal Med Ctr 1-21-1 Kanasugi Chiba Japan 2738588
Citazione:
A. Takeda et al., "Monitoring of p53 autoantibodies after resection of colorectal cancer: Relationship to operative curability", EURO J SURG, 167(1), 2001, pp. 50-53

Abstract

Objective: To investigate the clinical use of p53 autoantibodies as a marker in the postoperative monitoring of colorectal cancer. Design: Retrospective study. Setting: Teaching hospital, Japan. Subjects: 40 patients with colorectal cancer who had p53 autoantibodies in their serum preoperatively. Interventions: Serial assay of p53 autoantibodies by ELISA before and after resection. Main outcome measures: Interpretation by a qualitative analysis. Results: A significant correlation was observed between curability by surgical resection and postoperative disappearance of p53 autoantibodies. Twenty-seven (96%) of 28 patients, who had p53 autoantibodies and whose cancer was completely removed, had no such antibodies after resection and no recurrence after 7 to 26 months. Conclusions: Postoperative assays of p53 autoantibodies are potentially useful for predicting recurrence of colorectal cancer in patients who have p53 autoantibodies preoperatively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:02:22