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Titolo:
Nucleoside transport inhibition in ischemic myocardium results in enhancedtaurine efflux
Autore:
Zemgulis, V; Wikstrom, G; Henze, A; Waldenstrom, A; Thelin, S; Ronquist, G;
Indirizzi:
Univ Uppsala Hosp, Dept Cardiothorac Surg, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 c Surg, S-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Cardiol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ardiol, S-75185 Uppsala, Sweden Umea Univ Hosp, Dept Internal Med, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 pt Internal Med, S-90185 Umea, Sweden Univ Uppsala Hosp, Dept Clin Chem, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 n Chem, S-75185 Uppsala, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 143 - 154
SICI:
0014-2999(20010105)411:1-2<143:NTIIIM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG VENTRICULAR CARDIOMYOCYTES; RAT HEARTS; GUINEA-PIG; ADENOSINE PRODUCTION; REPERFUSION INJURY; PHOSPHOLIPID METHYLTRANSFERASE; INTRACELLULAR CONCENTRATION; BINDING-SITES; AMINO-ACIDS; DIPYRIDAMOLE;
Keywords:
myocardial infarction; nucleoside transport; adenosine; taurine; dipyridamole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Zemgulis, V Univ Uppsala Hosp, Dept Cardiothorac Surg, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 185 Uppsala, Sweden
Citazione:
V. Zemgulis et al., "Nucleoside transport inhibition in ischemic myocardium results in enhancedtaurine efflux", EUR J PHARM, 411(1-2), 2001, pp. 143-154

Abstract

We measured with the microdialysis technique energy-related metabolites inischemic myocardium over time in an experimental pig model. Emphasis was put on the dipyridamole effect when administered in the microdialysis probe inserted in ischemic myocardium. Not only adenosine but also taurine and pyruvate concentrations were significantly higher in the microdialysate during the periods of ischemia and extracorporeal circulation with cardioplegia. The enhanced efflux of taurine in ischemic myocardium induced by dipyridamole is a new finding. A mechanistic role of taurine in the prevention of Ca2+ overload in ischemic myocytes is discussed. Also, taurine may have stimulatory effects on glycolysis in ischemic heart. (C) 2001 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:23:49