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Titolo:
The effects of glutamate receptor agonists on neurotensin release using invivo microdialysis
Autore:
Radke, JM; Owens, MJ; Nemeroff, CB;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 129 - 134
SICI:
0014-2999(20010105)411:1-2<129:TEOGRA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; SUBSTANCE-P; RAT-BRAIN; INVIVO; STRIATUM; SYSTEMS; CHOLECYSTOKININ; TRANSMITTERS;
Keywords:
NMDA (N-methyl-D-aspartate); kainic acid; striatum; nucleus accumbens; medial prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nemeroff, CB Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, POB AF,1639 Pierce Dr, Atlanta, GA 30322 USA Emory Univ POB AF,1639 Pierce Dr Atlanta GA USA 30322 322 USA
Citazione:
J.M. Radke et al., "The effects of glutamate receptor agonists on neurotensin release using invivo microdialysis", EUR J PHARM, 411(1-2), 2001, pp. 129-134

Abstract

In the present study, extracellular concentrations of neurotensin were measured from the striatum, nucleus accumbens and the medial prefrontal cortexin;he awake, freely moving rat. Using a highly sensitive solid phase radioimmunoassay, basal concentrations of neurotensin were 2-5 pg/sample. In each region, glutamate receptor agonists, N-methyl-D-aspartate (NMDA) and kainic acid, increased neurotensin release 2-3-fold. Preincubation with the Nachannel blocker tetrodotoxin abolished the glutamate receptor agonist-induced increases except in the striatum following kainic acid infusion. These findings indicate that activation of glutamate receptors may indirectly stimulate neurotensin release. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:34:57