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Titolo:
Functional effects of corticosterone on 5-HT1A and 5-HT1B receptor activity in rat brain: in vivo microdialysis studies
Autore:
Gur, E; Dremencov, E; Lerer, B; Newman, ME;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Psychiat, Biol Psychiat Lab,IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 115 - 122
SICI:
0014-2999(20010105)411:1-2<115:FEOCO5>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; HIPPOCAMPAL CA1 NEURONS; DORSAL RAPHE NUCLEUS; ANTIDEPRESSANT DRUGS; ELECTROCONVULSIVE SHOCK; MESSENGER-RNA; GUINEA-PIG; IN-VIVO; MEDIATED HYPOTHERMIA; UNIPOLAR DEPRESSION;
Keywords:
5-HT (5-hydroxytryptamine, serotonin) corticosterone; hippocampus; cAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Newman, ME Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Psychiat, Biol Psychiat Lab,POB 12000, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem POB 12000 Jerusalem Israel IL-91120 rael
Citazione:
E. Gur et al., "Functional effects of corticosterone on 5-HT1A and 5-HT1B receptor activity in rat brain: in vivo microdialysis studies", EUR J PHARM, 411(1-2), 2001, pp. 115-122

Abstract

Glucocorticoid hormones are known to be elevated in depression, and to interact with serotonin 5-HT1A receptors at both the presynaptic and postsynaptic levels. Since one of the presumed mechanisms of action of antidepressant drugs is induction of changes in sensitivity of 5-HT1A and also 5-HT1B receptors. the effects of repeated administration of corticosterone (50 mg/kgs.c. b.i.d. for 10 days) on activities of these receptors were determined using in vivo microdialysis in freely moving rats. Presynaptic 5-HT1A receptor activity, as measured by the effect of a challenge dose (0.2 mg/kg s.c.) of the 5-HT1A agonist 8-hydroxy-2 (di-)-n-propylamino) tetralin (8-OH-DPAT) to reduce 5-HT levels in the hypothalamus. was not affected by corticosterone administration. Presynaptic 5-HT1B receptor activity, as measured by the effect of the 5-HT1B receptor antagonist (N-[4-methoxy-3-(4-methyl-1-piperizinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazole-3-yl)[1,1'-biphenyl]-carboxamide(GR 127935) (5 mg/kg s.c.) to increase 5-HT levels, was increased in hypothalamus but not hippocampus of corticosterone-treated rats. Postsynaptic 5-HT1A receptor activity, as measured by the effect of 8-OH-DPAT to increase cyclic AMP levels in the hippocampus. was not affected by corticosterone administration. The decrease in presynaptic 5-HT1B receptor activity after chronic administration of antidepressant drugs complements the increases in 5-HT1B receptor number observed in animal models of depression. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/04/20 alle ore 02:32:45