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Titolo:
Effects of intravenous and intrathecal sufentanil on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat
Autore:
Adam, F; Le Bars, D; Chauvin, M; Guirimand, F;
Indirizzi:
Hop Ambroise Pare, Serv Anesthesie Reanimat, AP HP, F-92104 Boulogne, France Hop Ambroise Pare Boulogne France F-92104 P HP, F-92104 Boulogne, France INSERM, U161, Unite Physiopharmacol Syst Nerveux, Paris, France INSERM Paris France , Unite Physiopharmacol Syst Nerveux, Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 93 - 106
SICI:
0014-2999(20010105)411:1-2<93:EOIAIS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MUSCLE RIGIDITY; ANTI-OPIOID PEPTIDES; DORSAL HORN NEURONS; PROTEIN-KINASE-C; NOCICEPTIVE RESPONSES; FIBER REFLEX; SPINAL-CORD; MAGNITUDE MEASUREMENT; BETA-FUNALTREXAMINE; WITHDRAWAL REFLEXES;
Keywords:
nociception; C-fibre reflex; sufentanil; intrinsic efficacy; facilitation; obex-transection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Guirimand, F Hop Ambroise Pare, Serv Anesthesie Reanimat, AP HP, F-92104 Boulogne, France Hop Ambroise Pare Boulogne France F-92104 Boulogne, France
Citazione:
F. Adam et al., "Effects of intravenous and intrathecal sufentanil on a C-fibre reflex elicited by a wide range of stimulus intensities in the rat", EUR J PHARM, 411(1-2), 2001, pp. 93-106

Abstract

A C-fibre reflex elicited by electrical stimulation within the territory of the sural nerve was recorded from the ipsilateral biceps femoris muscle in anaesthetised, intact rats, and in anaesthetised rats whose brains had been transected at the level of the obex. The temporal evolution of the response was studied by recording recruitment curves built with stimulus intensities from 0 to 10 times threshold. Both i.v. and i.t. sufentanil resulted in dose-dependent depressions of the reflex. Increasing the stimulus intensity from 1.5 to 10 times threshold resulted in an increase in the ED50 from 0.58 (0.40-0.86) to 2.40 (1.87-3.31) mug/kg for i.v. sufentanil and from 0.64 (0.46-0.79) to 1.63 (1.29-3.31) mug/kg for i.t. sufentanil. With increasing stimulus intensity, the dose-response curves showed a progressive shiftto the right, but this shift was only slight with the highest intensity stimuli. The ratios for the ED(50)s for i.v. to i.t. sufentanil were near 1. Following i.v. administration, sufentanil also facilitated the C-fibre reflex and produced tonic inter-stimulus discharges. They disappeared after thei.v. injection of naloxone. In the obex-transected rats, the depressive effect of sufentanil increased, while the facilitations and tonic inter-stimulus discharges disappeared. These findings suggest that the analgesic effects of i.v. ant i.t. sufentanil are similar, probably because sufentanil is highly soluble in lipids. Sufentanil-induced facilitations relate to supraspinal actions on motor controls and/or on the descending control of nociceptive transmission. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:14:00