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Titolo:
Occurrence of morphine tolerance and dependence in the nucleus paragigantocellularis neurons
Autore:
Saiepour, MH; Semnanian, S; Fathollahi, Y;
Indirizzi:
Univ Teheran, Inst Biochem & Biophys, Tehran, Iran Univ Teheran Tehran Iran Teheran, Inst Biochem & Biophys, Tehran, Iran Tarbiat Modarres Univ, Sch Med Sci, Dept Physiol, Tehran, Iran Tarbiat Modarres Univ Tehran Iran h Med Sci, Dept Physiol, Tehran, Iran
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 85 - 92
SICI:
0014-2999(20010105)411:1-2<85:OOMTAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROMEDIAL MEDULLA; LOCUS-COERULEUS NEURONS; NALOXONE-PRECIPITATED WITHDRAWAL; OPIATE-WITHDRAWAL; VENTROLATERAL MEDULLA; IN-VIVO; MEDIATED INHIBITION; INDUCED ACTIVATION; CERULEUS NEURONS; RAT;
Keywords:
nucleus paragigantocellularis; morphine tolerance; morphine dependence; naloxone; single unit recording;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Saiepour, MH Univ Teheran, Inst Biochem & Biophys, POB 13145-1384, Tehran,Iran Univ Teheran POB 13145-1384 Tehran Iran -1384, Tehran, Iran
Citazione:
M.H. Saiepour et al., "Occurrence of morphine tolerance and dependence in the nucleus paragigantocellularis neurons", EUR J PHARM, 411(1-2), 2001, pp. 85-92

Abstract

The occurrence of morphine tolerance and dependence in the nucleus paragigantocellularis neurons was investigated. The spontaneous activity was recorded from the nucleus paragigantocellularis neurons of urethane-anesthetizedrats. using single unit recording. Morphine microinjected (20 mg/ml, 120-200 nl) into the nucleus paragigantocellularis of control rats had both excitatory and inhibitory effects. These effects were reversed by microinjection of naloxone, revealing the possible involvement of mu receptors. Morphinemicroinjected into morphine-dependent rats failed to change the spontaneous activity of the nucleus paragigantocellularis neurons that accounts for the occurrence of tolerance to morphine in these neurons. Microinjection of naloxone (25 mg/ml. 120-200 nl) in control rats had no effect on the spontaneous firing rate of the nucleus paragigantocellularis neurons but in morphine-dependent rats, either alone or after morphine microinjection. naloxoneincreased neuronal activity significantly, indicating the occurrence of dependence on morphine in the nucleus paragigantocellularis neurons. These data show that the nucleus paragigantocellularis neurons may play a role in physical dependence on morphine. This conclusion is consistent with the finding, that activation of the nucleus paragigantocellularis by electrical stimulation in morphine-naive rats can elicit behaviors similar to those observed during naloxone-precipitated morphine withdrawal. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 27/09/20 alle ore 13:27:53