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Titolo:
The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia
Autore:
Bogaert, L; ONeill, MJ; Moonen, J; Sarre, S; Smolders, I; Ebinger, G; Michotte, Y;
Indirizzi:
Free Univ Brussels, Inst Pharmaceut, Dept Pharmaceut Chem & Drug Anal, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 nal, B-1090 Brussels, Belgium Eli Lilly & Co, Lilly Res Ctr, Windlesham GU20 6PH, Surrey, England Eli Lilly & Co Windlesham Surrey England GU20 6PH 20 6PH, Surrey, England Univ Hosp, Dept Neurol, B-1090 Brussels, Belgium Univ Hosp Brussels Belgium B-1090 Dept Neurol, B-1090 Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 71 - 83
SICI:
0014-2999(20010105)411:1-2<71:TEOLNA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL BLOCKER; ISCHEMIC BRAIN INJURY; N-TYPE; STRIATAL DOPAMINE; CELL-DEATH; RAT-BRAIN; INTRACEREBRAL MICRODIALYSIS; GLUTAMATE RELEASE; CA2+ CHANNELS; BLOOD-FLOW;
Keywords:
Ca2+ channel blocker; LY393613; nimodipine; verapamil; ischaemia, focal; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Michotte, Y Free Univ Brussels, Inst Pharmaceut, Dept Pharmaceut Chem & Drug Anal, Laarbeeklaan 103, B-1090 Brussels, Belgium Free Univ Brussels Laarbeeklaan 103 Brussels Belgium B-1090 m
Citazione:
L. Bogaert et al., "The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia", EUR J PHARM, 411(1-2), 2001, pp. 71-83

Abstract

This study evaluates the effects of N-(2-[bis (4-fluorophenyl)methoxy]ethyl)-1-butanamine hydrochloride (LY393613), a novel neuronal (N/P/Q-type) Ca2 channel blocker, in ischaemia. For comparison. two commonly used L-type Ca2+ channel blockers: nimodipine and verapamil were also evaluated. Ischaemia was induced in freely moving rats by micro-injection of endothelin-l near the middle cerebral artery. In vivo microdialysis, laser Doppler flowmetry and histology were used to monitor ischaemia. Administration of LY393613,before and after the insult. attenuated the ischaemia-induced glutamate release, but not the dopamine release. Both nimodipine and verapamil failed to affect transmitter releases significantly, when administered post-occlusion. None of the compounds tested, produced any significant change in striatal blood flow. Histology showed that ischaemic damage was significantly less in LY393613 pre-treated rats, In conclusion. LY393613. a neuronal N/P/Q-Ca2+ channel blocker, can attenuate ischaemic brain damage. The protective mechanism appears to be mainly the attenuation of the ischaemia-induced glutamate release, rather than its effect on cerebral hemodynamics. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:57:45