Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antidepressants alter cell proliferation in the adult brain in vivo and inneural cultures in vitro
Autore:
Manev, H; Uz, T; Smalheiser, NR; Manev, R;
Indirizzi:
Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Inst Psychiat, Chicago, IL 60612 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 411, anno: 2001,
pagine: 67 - 70
SICI:
0014-2999(20010105)411:1-2<67:AACPIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOXETINE;
Keywords:
antidepressant; fluoxetine; hippocampus; neurogenesis; cerebellar granule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Manev, H Univ Illinois, Dept Psychiat, Inst Psychiat, 1601 W Taylor St,MC 912, Chicago, IL 60612 USA Univ Illinois 1601 W Taylor St,MC 912 Chicago ILUSA 60612 12 USA
Citazione:
H. Manev et al., "Antidepressants alter cell proliferation in the adult brain in vivo and inneural cultures in vitro", EUR J PHARM, 411(1-2), 2001, pp. 67-70

Abstract

The action of antidepressants on cell proliferation (bromodeoxyuridine (BrdU) or [H-3]thymidine incorporation} was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells)in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitoneal treatment with fluoxetine (5 mg/kg) resulted in a 3.4-fold increase of bromodeoxyuridine-positive cells in the subgranular zone of the dentate gyrus. In cell cultures, at 1 and 10 days in vitro, 48-h fluoxetine exposure (1 muM. which is comparable to therapeutic plasma concentrations) reduced thymidine incorporation when initiated at 1 day in vitro, but increased cell proliferation when initiated at 10 days in vitro. Clomipramine and imipramine produced similar action in vitro; desipramine was ineffective. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:29:21