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Titolo:
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice
Autore:
NicNiocaill, B; Haraldsson, B; Hansson, O; OConnor, WT; Brundin, P;
Indirizzi:
Univ Lund, Dept Physiol Sci, Sect Neuronal Survival, Wallenberg Neurosci Ctr, S-22184 Lund, Sweden Univ Lund Lund Sweden S-22184 lenberg Neurosci Ctr, S-22184 Lund, Sweden Univ Dublin Trinity Coll, Dept Human Anat & Physiol, Conway Inst Biomol & Biomed Res, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 Biomed Res, Dublin 2, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 206 - 210
SICI:
0953-816X(200101)13:1<206:ASAANR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL INTRANUCLEAR INCLUSIONS; DUAL-PROBE MICRODIALYSIS; D-ASPARTIC ACID; EXTRACELLULAR DOPAMINE; GLUTAMATE TRANSPORTER; INVIVO MICRODIALYSIS; DISEASE MUTATION; BASAL GANGLIA; MOUSE MODELS; GABA RELEASE;
Keywords:
aspartate; corticostriatal; GABA; glutamate; neurodegeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Brundin, P Univ Lund, Dept Physiol Sci, Sect Neuronal Survival, WallenbergNeurosci Ctr, BMC A10, S-22184 Lund, Sweden Univ Lund BMC A10 Lund SwedenS-22184 10, S-22184 Lund, Sweden
Citazione:
B. NicNiocaill et al., "Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice", EUR J NEURO, 13(1), 2001, pp. 206-210

Abstract

Huntington's disease is an autosomal dominant disease which presents with striatal and cortical degeneration causing involuntary movements, dementia and emotional changes. We employed 18-week-old transgenic Huntington mice (R6/1 line developed by Bates and coworkers) that express exon 1 of the mutant human Huntington gene with 115 CAG triplet repeats, At this age, R6/1 mice do not exhibit an overt neurological phenotype nor any striatal neuronalloss. Using microdialysis, we monitored basal and intrastriatal N-methyl D-aspartate (NMDA, 100 muM, 15 min)- and KCI (100 mM, 15 min)-induced increases in local aspartate, glutamate and GABA release in halothane-anaesthetized transgenic mice and wild-type controls. Basal striatal dialysate glutamate levels were reduced by 42% in R6/1 mice whilst aspartate and GABA levelsdid not differ from those observed in control mice. Intrastriatal NMDA wasassociated with significantly greater aspartate (at 15 min) and GABA (at 30 min) levels in the R6/1 mice compared to controls, whilst glutamate release rapidly increased to the same extent in both groups, Intrastriatal KCI was associated with enhanced increases (30 min) in local aspartate and glutamate release in the R6/1 mice above those observed in controls whilst the rapid increase (15 min) in GABA release was similar in both groups, The results provide compelling evidence for specific alterations in both basal, as well as NMDA- and KCl-induced, release of striatal amino acid neurotransmitters in this transgenic model of Huntington's disease, even in the absence of manifest neurodegeneration.

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Documento generato il 02/04/20 alle ore 19:14:15