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Titolo:
Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule
Autore:
Nakamura, K; Manabe, T; Watanabe, M; Mamiya, T; Ichikawa, R; Kiyama, Y; Sanbo, M; Yagi, T; Inoue, Y; Nabeshima, T; Mori, H; Mishina, M;
Indirizzi:
Univ Tokyo, Dept Mol Neurobiol & Pharmacol, Grad Sch Med, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 macol, Grad Sch Med, Tokyo 1130033, Japan Japan Sci & Technol Corp, CREST, Tokyo 1130033, Japan Japan Sci & Technol Corp Tokyo Japan 1130033 CREST, Tokyo 1130033, Japan Kobe Univ, Sch Med, Dept Physiol, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 pt Physiol, Kobe, Hyogo 6500017, Japan Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Nagoya Univ, Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668560, Japan Nagoya Univ Nagoya Aichi Japan 4668560 harm, Nagoya, Aichi 4668560, Japan Natl Inst Physiol Sci, Lab Neurobiol & Behav Genet, Okazaki, Aichi 4440867, Japan Natl Inst Physiol Sci Okazaki Aichi Japan 4440867 i, Aichi 4440867, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 179 - 189
SICI:
0953-816X(200101)13:1<179:EOHLRM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NMDA RECEPTOR-CHANNEL; ACOUSTIC STARTLE REFLEX; L1 KNOCKOUT MICE; SYNAPTIC PLASTICITY; PREPULSE INHIBITION; NERVOUS-SYSTEM; EPSILON-1 SUBUNIT; OLFACTORY-BULB; N-CAM;
Keywords:
learning; prepulse inhibition; synaptic plasticity; telencephalin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Mishina, M Univ Tokyo, Dept Mol Neurobiol & Pharmacol, Grad Sch Med, Tokyo1130033, Japan Univ Tokyo Tokyo Japan 1130033 Sch Med, Tokyo 1130033, Japan
Citazione:
K. Nakamura et al., "Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule", EUR J NEURO, 13(1), 2001, pp. 179-189

Abstract

Telencephalin (TLCN) is a cell adhesion molecule selectively expressed in the telencephalon of the mammalian brain. The mutant mice lacking TLCN had no detectable abnormalities in their neural development and synaptic structures. Ablation of TLCN increased the hippocampal long-term potentiation andits saturation level. The TLCN mutation selectively enhanced the performance of the radial maze and water-finding tasks, learning tasks with appetitive reinforcers, but not the contextual fear conditioning and Morris water maze tasks with aversive stimuli for conditioning. Furthermore, the TLCN mutant mice showed an increase of prepulse inhibition of the acoustic startle response. These results suggest that TLCN is a determinant of the dynamic range of synaptic plasticity and plays roles in reward-motivated learning and memory and sensorimotor gating.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:56:48