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Titolo:
Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice
Autore:
Hutcheson, DM; Matthes, HWD; Valjent, E; Sanchez-Blazquez, P; Rodriguez-Diaz, M; Garzon, J; Kieffer, BL; Maldonado, R;
Indirizzi:
Univ Pompeu Fabra, Fac Ciences Salut & Vida, Lab Neurofarmacol, E-08003 Barcelona, Spain Univ Pompeu Fabra Barcelona Spain E-08003 acol, E-08003 Barcelona, Spain Univ Paris 05, Fac Pharm, Dept Pharmacol Mol & Struct, INSERM,U266,URA D1500 CNRS, F-75270 Paris 06, France Univ Paris 05 Paris France 06 6,URA D1500 CNRS, F-75270 Paris 06, France Univ Louis Pasteur Strasbourg 1, Ecole Super Biotechnol Strasbourg, CNRS, Unite Propre Rech 9050, F-67400 Illkirch, France Univ Louis Pasteur Strasbourg 1 Illkirch France F-67400 Illkirch, France CSIC, Inst Neurobiol Santiago Ramon & Cajal, Madrid 28002, Spain CSIC Madrid Spain 28002 biol Santiago Ramon & Cajal, Madrid 28002, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 153 - 161
SICI:
0953-816X(200101)13:1<153:LODARE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; CHRONIC MORPHINE TREATMENT; HUMAN OPIATE ADDICTS; PHYSICAL-DEPENDENCE; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; ANTINOCICEPTIVE TOLERANCE; MEDIATED ANTINOCICEPTION; PLACE-PREFERENCE; BETA-ENDORPHIN;
Keywords:
delta opioid agonist; opioid receptor; opioid withdrawal; place preference; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Maldonado, R Univ Pompeu Fabra, Fac Ciences Salut & Vida, Lab Neurofarmacol, Doctor Aiguader 80, E-08003 Barcelona, Spain Univ Pompeu Fabra Doctor Aiguader 80 Barcelona Spain E-08003
Citazione:
D.M. Hutcheson et al., "Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice", EUR J NEURO, 13(1), 2001, pp. 153-161

Abstract

We have previously shown that the antinociceptive effects produced by the delta opioid-selective agonist deltorphin II are preserved in mu-opioid receptor (MOR)-deficient mice. We have now investigated rewarding effects and physical dependence produced by deltorphin II in these animals. Wild-type and MOR-deficient mice were implanted with a cannula into the third ventricle and deltorphin II was administered centrally. The rewarding effects induced by deltorphin Ii were then investigated using the place preference paradigm. Wild-type mice showed place preference for the compartment previously associated with deltorphin Il and this effect was not observed in MOR-deficient mice. In a second experiment, mice received a chronic perfusion of deltorphin Il over 6 days, via an Alzet minipump connected to the intraventricular cannula, and withdrawal was precipitated by naloxone administration. Wild-type animals showed a moderate but significant incidence of several somatic signs of withdrawal. This withdrawal response was suppressed in MOR-deficient mice. Analysis of the immunoreactivity levels of PKC-alpha, PKC-beta (I and II) and PKC-gamma isozymes in the cerebral cortex of mice infused chronically with deltorphin II showed a significant up-regulation of all these isozymes in the soluble fraction in wild-type but not in MOR-deficient mice. In conclusion, mu-opioid receptors, which are not involved in deltorphin II antinociception, appear to mediate the effects of chronic deltorphinII on rewarding responses, physical dependence and adaptive changes to PKC.

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Documento generato il 04/07/20 alle ore 20:02:58