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Titolo:
Visual interhemispheric transfer to areas 17 and 18 in cats with convergent strabismus
Autore:
Milleret, C; Houzel, JC;
Indirizzi:
Coll France, CNRS, UMR 9950, Lab Physiol Percept & Act, F-75005 Paris, France Coll France Paris France F-75005 ol Percept & Act, F-75005 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 137 - 152
SICI:
0953-816X(200101)13:1<137:VITTA1>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUINT-INDUCED MODIFICATION; RECEPTIVE-FIELD PROPERTIES; STRIATE CORTEX NEURONS; CORPUS-CALLOSUM; POSTNATAL-DEVELOPMENT; RETINOTOPIC ORGANIZATION; BINOCULAR INTERACTIONS; RESPONSE PROPERTIES; CORTICAL-NEURONS; ADULT CAT;
Keywords:
callosal connections; development; interhemispheric integration; plasticity; primary visual cortex; single-unit recordings;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Milleret, C Coll France, CNRS, UMR 9950, Lab Physiol Percept & Act, 11 Pl Marcelin Berthelot, F-75005 Paris, France Coll France 11 Pl Marcelin Berthelot Paris France F-75005 nce
Citazione:
C. Milleret e J.C. Houzel, "Visual interhemispheric transfer to areas 17 and 18 in cats with convergent strabismus", EUR J NEURO, 13(1), 2001, pp. 137-152

Abstract

Commissural connections between primary visual cortical maps of the two hemispheres are essential to unify the split representation of the visual field. in normal adult cats, callosal connections are essentially restricted to the border between areas A17 and A18, where the central vertical meridianis projected. In contrast, early convergent strabismus leads to an expanded callosal-receiving zone, as repeatedly indicated by anatomical experiments. We investigated here the functional correlates of this widespread distribution of callosal terminals by analysing transcallosal visual responses infive anaesthetized and paralysed 4-10-month-old cats whose right eye had been surgically deviated on postnatal day 6. After acute section of the optic chiasm, single-unit activity was recorded from A17 and A18 of the right hemisphere while the left eye was visually stimulated. A total of 108/406 units were transcallosally activated. While they were more frequent at the 17/18 border (46% of the units recorded within this region), numerous transcallosally activated units were located throughout A17 (16%), A18 (27%) or within the white matter (17%). In all regions, transcallosally driven units displayed functional deficits usually associated with strabismus, such as decreased binocularity and ability to respond to fast-moving stimuli, and increased receptive field size. Many units also displayed reduced orientation selectivity and increased position disparity. In addition, transcallosal receptive fields were manifestly located within the hemifield ipsilateral to the explored cortex, with almost no contact with the central vertical meridian. Comparison with data from normal adults revealed that strabismus induced a considerable expansion of the callosal receiving zone, both in terms of the cortical region and of the extent of the visual field involved in interhemispheric transfer, with implications in the integration of visual information across the hemispheres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 05:33:36