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Titolo:
The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons
Autore:
Nogradi, A; Vrbova, G;
Indirizzi:
Univ Szeged, Albert Szent Gyorgyi Med Ctr, Dept Ophthalmol, H-6720 Szeged,Hungary Univ Szeged Szeged Hungary H-6720 Dept Ophthalmol, H-6720 Szeged,Hungary Univ Coll London, Dept Anat & Dev Biol, London, England Univ Coll London London England , Dept Anat & Dev Biol, London, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 113 - 118
SICI:
0953-816X(200101)13:1<113:TEORTI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; SPINAL-CORD GRAFTS; ROOT AVULSION; RECEPTORS; ISCHEMIA; MUSCLES; MK-801; DEATH;
Keywords:
damaged motoneurons; embryonic grafts; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Nogradi, A Univ Szeged, Albert Szent Gyorgyi Med Ctr, Dept Ophthalmol, Koranyi Fasor 10-11, H-6720 Szeged, Hungary Univ Szeged Koranyi Fasor 10-11 Szeged Hungary H-6720 Hungary
Citazione:
A. Nogradi e G. Vrbova, "The effect of riluzole treatment in rats on the survival of injured adult and grafted embryonic motoneurons", EUR J NEURO, 13(1), 2001, pp. 113-118

Abstract

The effect of riluzole on the survival of injured motoneurons was studied. The L4 ventral root was avulsed and reimplanted into the spinal cord. Immediately after the operation, 4 animals were treated with riluzole for 3 weeks while another 4 animals received no treatment after the operation. Threemonths later the fluorescent dyes, Fast Blue and Diamidino Yellow, were applied to the cut ventral ramus of the L4 spinal nerve, for retrograde labelling of neurons. Three days later, the spinal cords were processed to reveal the retrograde-labelled cells. In untreated animals, there were 20 +/- 2.1 labelled neurons (+/- SEM), while in animals treated with riluzole there were 723 +/- 26. Thus, treatment with riluzole dramatically enhanced the survival of injured motoneurons. In another series of experiments, after avulsion of the L4 ventral root and its reinsertion, embryonic spinal cord pieces were grafted into the host cord. Five animals received riluzole treatment and 4 were left untreated. In the untreated animals, 125 +/- 5.1 retrograde-labelled cells of both graft and host origin were detected. In rats treated with riluzole, 645 +/- 35.7 retrograde-labelled cells were seen and almost all of these were of host origin. Thus, treatment with riluzole enhanced the survival of injured host motoneurons, and by doing so, (i) reduced the ability of grafted neurons to extend their axons into the reimplanted L4 ventral root, and (ii) reduced the survival of the grafted cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:49:24