Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism
Autore:
Sakai, K; Crochet, S;
Indirizzi:
Univ Lyon 1, Dept Expt Med, INSERM, U480, F-69373 Lyon 08, France Univ Lyon 1 Lyon France 08 pt Med, INSERM, U480, F-69373 Lyon 08, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 103 - 112
SICI:
0953-816X(200101)13:1<103:RODRNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING CATS; UNIT-ACTIVITY; BRAIN-STEM; 5-HT1A AUTORECEPTORS; RECEPTOR AGONIST; BEHAVING CATS; WAKING CYCLE; CELL-BODIES; RAT-BRAIN; NUCLEUS;
Keywords:
extracellular unit recordings; microdialysis; narcolepsy; sleep; wakefulness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, K Univ Lyon 1, Dept Expt Med, INSERM, U480, 8 Ave Rockefeller, F-69373 Lyon 08, France Univ Lyon 1 8 Ave Rockefeller Lyon France 08 373 Lyon 08, France
Citazione:
K. Sakai e S. Crochet, "Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism", EUR J NEURO, 13(1), 2001, pp. 103-112

Abstract

Using in vivo microdialysis either alone or in combination with extracellular unit recordings, we have examined the effect of serotonergic and nonserotonergic drugs applied to the dorsal raphe nucleus (DRN) on behavioural states in the cat. We found that 8-hydroxy-2-(n-dipropylamino)tetralin hydrobromide (8-OH-DPAT), a selective 5-HT1A receptor agonist, induced a dose-dependent increase in wakefulness (W) and decrease in deep slow-wave sleep (SWS), but had no significant effect on the generation of paradoxical sleep (PS) at concentrations of 5-500 muM At the highest concentration tested, however, PS occurred directly after W, as in narcolepsy. N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide maleate (WAY-100635), a selective 5-HT1A receptor antagonist, had no effect on overall behavioural states at concentrations of 50 or 500 muM. Muscimol, a potent GABA(A) receptor agonist, had little or no effect at concentrations of 10, 50or 100 muM, but concentrations of 500 or 1000 muM caused a pronounced increase in W and decrease in SWS without inducing any changes in the amount ofPS, although PS episodes occurred as in narcolepsy. Bicuculline, a GABA(A)receptor antagonist, or kainate, an excitatory amino acid agonist, produced a dose-dependent increase in W and decrease in deep SWS and PS. Extracellular unit recordings combined with microdialysis infusion into the DRN demonstrated that only high concentrations of 8-OH-DPAT or muscimol significantly affect a large population of DRN neurons. Taken together, these findingsindicate that DRN serotonergic activity does not play any crucial role in PS generation, but is involved in the regulation of W and SWS as well as innarcolepsy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:45