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Titolo:
NMDA-dependent, network-driven oscillatory activity induced by bicucullineor removal of Mg2+ in rat olfactory bulb neurons
Autore:
Puopolo, M; Belluzzi, O;
Indirizzi:
Univ Ferrara, Dipartimento Sci Biomed & Terapie Avanzate, Sez Fisiol Umana, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 Fisiol Umana, I-44100 Ferrara, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 92 - 102
SICI:
0953-816X(200101)13:1<92:NNOAIB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; IN-VITRO; PIRIFORM CORTEX; DENDRODENDRITIC INHIBITION; GABAERGIC MODULATION; PERIGLOMERULAR CELLS; NEOCORTICAL SLICES; HIPPOCAMPAL SLICE; STRIATE CORTEX; NERVOUS-SYSTEM;
Keywords:
NMDA receptor; oscillations; plasticity; synaptic integration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Belluzzi, O Univ Ferrara, Dipartimento Sci Biomed & Terapie Avanzate, Sez Fisiol Umana, Via Fossato Mortara 17-19, I-44100 Ferrara, Italy Univ Ferrara Via Fossato Mortara 17-19 Ferrara Italy I-44100
Citazione:
M. Puopolo e O. Belluzzi, "NMDA-dependent, network-driven oscillatory activity induced by bicucullineor removal of Mg2+ in rat olfactory bulb neurons", EUR J NEURO, 13(1), 2001, pp. 92-102

Abstract

Spontaneous, low-frequency voltage oscillations (LFOs) were observed in the neurons of rat olfactory bulb upon disinhibition with GABA(A) antagonistsand/or removal of Mg2+ from external saline, Ordinarily, LFOs presented a highly organized temporal structure, with bursts recurring regularly at about 0.05 Hz. Slow depolarizing shifts with similar frequencies were observedin all types of bulbar neurons. Simultaneous recordings from mutually independent neurons showed that LFOs were highly synchronized in distinct cells. The occurrence of LFOs was prevented by NMDA, but not AMPA/kainate, receptor antagonists. The oscillations were also halted by Ca2+ antagonists and tetrodotoxin. The pace of the oscillations was reset by stimulation of the olfactory nerve but not by direct injection of depolarizing current into the oscillating cell. Removal of the outer portion of the slice with a cut along the external plexiform layer provided crucial evidence that the bursting activity first initiated in the glomerular region and propagated synaptically downstream towards the inner layers, suggesting an organizing role forolfactory glomeruli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:27:00