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Titolo:
Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neurons
Autore:
Gonzalez-Hernandez, T; Barroso-Chinea, P; Acevedo, A; Salido, E; Rodriguez, M;
Indirizzi:
Univ La Laguna, Fac Med, Dept Anat, Tenerife, Spain Univ La Laguna Tenerife Spain guna, Fac Med, Dept Anat, Tenerife, Spain Univ La Laguna, Hosp Univ Canarias, Unidad Invest, Tenerife, Spain Univ LaLaguna Tenerife Spain Canarias, Unidad Invest, Tenerife, Spain Univ La Laguna, Fac Med, Dept Fisiol, Tenerife, Spain Univ La Laguna Tenerife Spain na, Fac Med, Dept Fisiol, Tenerife, Spain
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 57 - 67
SICI:
0953-816X(200101)13:1<57:COTHAG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; MESSENGER-RNA LEVELS; VENTRAL TEGMENTAL AREA; IN-VIVO MICRODIALYSIS; NIGRA PARS RETICULATA; RAT SUBSTANTIA-NIGRA; GABA-B RECEPTORS; BASAL GANGLIA; 2 FORMS; NIGROSTRIATAL PATHWAY;
Keywords:
cotransmission; dopamine; GABA; rat; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Gonzalez-Hernandez, T Univ La Laguna, Fac Med, Dept Anat, Tenerife, Spain Univ La Laguna Tenerife Spain at, Tenerife, Spain
Citazione:
T. Gonzalez-Hernandez et al., "Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neurons", EUR J NEURO, 13(1), 2001, pp. 57-67

Abstract

Although dopamine has been considered as the only neurotransmitter in the nigrostriatal pathway, studies carried out in the last two decades have suggested the existence of a nondopaminergic nigrostriatal projection, and more recently, gamma -aminobutyric acid (GABA) has been identified as its neurotransmitter. In this study, we used the combination of immunocytochemistryfor tyrosine hydroxylase (TH; a marker of dopaminergic neurons), in situ hybridization (ISH) for two different isoforms of glutamic acid decarboxylase (GAD65 and GAD67, the rate-limiting enzyme in GABA synthesis) and retrograde tracing techniques to investigate the possible existence of nigrostriatal neurons containing both neurotransmitters (dopamine and GABA) in the rat. Our results revealed that approximately 10% of mesostriatal dopaminergic neurons, most of them lying in the medial region of the substantia nigra pars compacta (SNC) and neighbouring A10 region, contain GAD65 mRNA. These findings reveal a third nigrostriatal pathway formed by dopaminergic/GABAergic neurons. Contrasting with the idea that in the basal ganglia, dopamine and GABA are released from different cell populations, the results suggest a more complex dopamine/GABA interaction than previously assumed, probably including cotransmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:40:56