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Titolo:
TrkA-expressing trigeminal sensory neurons display both neurochemical and structural plasticity despite a loss of p75(NTR) function: responses to normal and elevated levels of nerve growth factor
Autore:
Krol, KM; Stein, EJ; Elliott, J; Kawaja, MD;
Indirizzi:
Queens Univ, Dept Anat & Cell Biol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 Biol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 35 - 47
SICI:
0953-816X(200101)13:1<35:TTSNDB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
P75 NEUROTROPHIN RECEPTOR; AFFINITY NGF RECEPTOR; MESSENGER-RNA EXPRESSION; ROOT GANGLION NEURONS; GENE-RELATED PEPTIDE; SYMPATHETIC NEURONS; MICE LACKING; DEVELOPMENTAL-CHANGES; FACTOR BINDING; TARGET ORGANS;
Keywords:
afferent; mRNA expression; nociceptive; receptor; spinal tract; sprouting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kawaja, MD Queens Univ, Dept Anat & Cell Biol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 ton, ON K7L 3N6, Canada
Citazione:
K.M. Krol et al., "TrkA-expressing trigeminal sensory neurons display both neurochemical and structural plasticity despite a loss of p75(NTR) function: responses to normal and elevated levels of nerve growth factor", EUR J NEURO, 13(1), 2001, pp. 35-47

Abstract

In neural crest-derived sensory ganglia, approximately half of the neuronal population expresses the transmembrane trkA receptor that is required forneuronal binding of target-derived nerve growth factor (NGF). These same neurons also express the p75 neurotrophin receptor (NTR) that increases the affinity of trkA for NGF. Depleting p75(NTR) expression reduces both the survival of trkA-positive sensory neurons and their afferent innervation of peripheral targets. in this investigation, we assessed the neurochemical andstructural plasticity of trigeminal sensory neurons in p75(NTR)-deficient mice in response to either normal or elevated levels of NGF during postnatal development and into adulthood. Although p75(NTR)-deficient mice have 30%fewer trigeminal neurons, levels of trkA mRNA expression are modestly elevated in these mutant mice as compared to control mice. The density of central afferent axons and local levels of NGF are, however, comparable between mutant and control animals. Thus, despite the survival of fewer trigeminal neurons, neither ganglionic levels of trkA mRNA expression nor the density of central afferent projections are depleted in p75(NTR)-deficient mice. Inresponse to elevated levels of NGF protein, transgenic mice with and without p75(NTR) expression display both increased levels of trkA mRNA expression and a greater density of trigeminal central afferent axons as compared tocontrol mice. These data further reveal that an absence of p75(NTR) function in trigeminal sensory neurons does not diminish their capacity for NGF-dependent plasticity, namely trkA mRNA expression and collateral growth of central afferent axons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:22:48