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Titolo:
Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina
Autore:
Hack, I; Frech, M; Dick, O; Peichl, L; Brandstatter, JH;
Indirizzi:
Max Planck Inst Hirnforsch, Abt Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 15 - 24
SICI:
0953-816X(200101)13:1<15:HDOAGR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONE BIPOLAR CELLS; CENTRAL-NERVOUS-SYSTEM; MAMMALIAN RETINA; RAT RETINA; CAT RETINA; LOCALIZATION; MGLUR1-ALPHA; PHARMACOLOGY; EXPRESSION; CHANNELS;
Keywords:
bipolar cells; horizontal cells; immunoelectron microscopy; ionotropic glutamate receptors; mouse retina; rat retina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Brandstatter, JH Max Planck Inst Hirnforsch, Abt Neuroanat, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Deutschordenstr46 Frankfurt Germany D-60528
Citazione:
I. Hack et al., "Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina", EUR J NEURO, 13(1), 2001, pp. 15-24

Abstract

In the retina the segregation of different aspects of visual information starts at the first synapse in signal transfer from the photoreceptors to the second-order neurons, via the neurotransmitter glutamate. We examined thedistribution of the four AMPA glutamate receptor subunits GluR1-GluR4 at the photoreceptor synapses in mouse and rat retinae by light and immunoelectron microscopy and serial section reconstructions. On the dendrites of OFF-cone bipolar cells, which make flat, noninvaginating contacts postsynaptic at cone synaptic terminals, the subunits GluR1 and GluR2 were predominantlyfound. Horizontal cell processes postsynaptic at both rod and cone synaptic terminals preferentially expressed the subunits GluR2, GluR2/3 and GluR4. An intriguing finding was the presence of GluR2/3 and GluR4 subunits on dendrites of putative rod bipolar cells, which are thought to signal through the sign-inverting metabotropic glutamate receptor 6, mGluR6. Furthermore, at the rod terminals, horizontal cell processes and rod bipolar cell dendrites showed labelling for the AMPA receptor subunits at the ribbon synaptic site or perisynaptically at their site of invagination into the rod terminal. The wide distribution of AMPA receptor subunits at the photoreceptor synapses suggests that AMPA receptors play an important role in visual signal transfer from the photoreceptors to their postsynaptic partners.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 07:23:36