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Titolo:
Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
Autore:
Vaudano, E; Rosenblad, C; Bjorklund, A;
Indirizzi:
Univ Lund, Wallenberg Neurosci Ctr, Dept Physiol Sci, S-22362 Lund, SwedenUniv Lund Lund Sweden S-22362 tr, Dept Physiol Sci, S-22362 Lund, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 1 - 14
SICI:
0953-816X(200101)13:1<1:IICEAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-INDUCED APOPTOSIS; CEREBELLAR GRANULE NEURONS; SUBSTANTIA-NIGRA; IN-VIVO; SYMPATHETIC NEURONS; ADULT-RAT; PARKINSONS-DISEASE; PROTEIN-KINASE; INTRASTRIATAL 6-HYDROXYDOPAMINE; PHOSPHATIDYLINOSITOL 3-KINASE;
Keywords:
6-OHDA; c-Jun; excitotoxic lesion; GDNF; neuronal cell death; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Vaudano, E H Lundbeck AS, Dept Neurodegenerat Dis, Ottiljavej 9, DK-2500 Valby, Denmark H Lundbeck AS Ottiljavej 9 Valby Denmark DK-2500 alby, Denmark
Citazione:
E. Vaudano et al., "Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor", EUR J NEURO, 13(1), 2001, pp. 1-14

Abstract

This study was designed to determine whether induction and phosphorylationof the transcription factor c-Jun is associated with lesion-induced death of dopaminergic neurons of the substantia nigra pars compacta, and if this cellular response is modulated by glial-cell-line-derived neurotrophic factor. In adult rats, delayed dopaminergic neuron cell death induced by intrastriatal B-hydroxydopamine injection led to a marked increase in the number of both c-Jun- and phosphorylated cJun-immunoreactive nuclei in the substantia nigra pars compacta. The response was maximal before any significant loss of nigral neurons could be detected (on day 7 post lesion) and was confined to the dopaminergic neurons. Similarly, 6-hydroxydopamine lesion of thestriatal dopaminergic terminals or excitotoxic lesion of the striatal target neurons in neonatal rats resulted in an increased number of c-Jun- and phosphorylated cJun-immunoreactive nigral nuclei that preceded the loss of nigral dopaminergic neurons. By contrast, after an excitotoxic lesion of thestriatal target neurons in the adult rat, resulting in atrophy but not cell death of the nigral dopaminergic neurons, no upregulation of either c-Junor phosphorylated c-Jun was found. A single injection of 10 mug of glial-cell-line-derived-neurotrophic factor given at day 3 after the intrastriatal6-hydroxydopamine lesion reduced the number of c-Jun- and phosphorylated c-Jun-immunoreactive nuclei in the substantia nigra and protected the dopaminergic neurons from the ensuing cell death. We conclude that c-Jun induction and phosphorylation! may be involved in the cellular events leading to death of nigral dopaminergic neurons in vivo and that this response can be modulated by glial-cell-line-derived-neurotrophic factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:51:56