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Titolo:
Strain-specific TCR repertoire selection of IL-4-producing Thy-1(dull) gamma delta thymocytes
Autore:
Azuara, V; Grigoriadou, K; Lembezat, MP; Nagler-Anderson, C; Pereira, P;
Indirizzi:
Inst Pasteur, CNRS, URA 1961, Unite Dev Lymphocytes, F-75724 Paris 15, France Inst Pasteur Paris France 15 e Dev Lymphocytes, F-75724 Paris 15, France Massachusetts Gen Hosp, Mucosal Immun Lab, Charlestown, MA USA Massachusetts Gen Hosp Charlestown MA USA Immun Lab, Charlestown, MA USA Harvard Univ, Sch Med, Charlestown, MA USA Harvard Univ Charlestown MA USA rvard Univ, Sch Med, Charlestown, MA USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 31, anno: 2001,
pagine: 205 - 214
SICI:
0014-2980(200101)31:1<205:STRSOI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL RECEPTOR-ALPHA/BETA(+) CELLS; RECEPTOR-ALPHA-CHAIN; T-CELLS; CD8 THYMOCYTES; GENE FAMILIES; PRODUCE IL-4; BONE-MARROW; MICE; SUBSET; DIVERSE;
Keywords:
gamma delta T lymphocyte; T cell development; thymus; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira, P Inst Pasteur, CNRS, URA 1961, Unite Dev Lymphocytes, 25 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Dr Roux Paris France 154 Paris 15, France
Citazione:
V. Azuara et al., "Strain-specific TCR repertoire selection of IL-4-producing Thy-1(dull) gamma delta thymocytes", EUR J IMMUN, 31(1), 2001, pp. 205-214

Abstract

Thy-1(dull) gamma delta thymocytes constitute an unusual subset of mature TCR gamma delta cells which share with NK T cells the expression of cell surface markers usually associated with activated or memory cells and the simultaneous production of high levels of IL-4 and IFN-gamma upon activation. In DBA/2 mice, Thy-1(dull) gamma delta thymocytes express a restricted repertoire of TCR that are composed of the V gamma1 gene product mainly associated with V delta6.4 chains exhibiting very limited junctional sequence diversity. In this study we have characterized this gamma delta T cell population in different strains of mice and show that Thy-1(dull) gamma delta thymocytes are present in every strain tested, albeit at different frequencies. Moreover IL-4 production by gamma delta thymocytes is mainly confined to the Thy-1(dull) gamma delta population in every strain tested. Finally, the repertoire of TCR expressed by Thy-1(dull) gamma delta thymocytes varies in different strain of mice, although a biased expression of V gamma1 and V delta6 chains was observed in all strains studied. However, the extent of junctional diversity of the V gamma1 and V delta6 chains expressed by Thy-1(dull) gamma delta thymocytes varied from oligoclonal in DBA/2 mice to polyclonal in FVB/N mice. Thy-1(dull) gamma delta thymocytes from mouse strains such as C3H/HeJ and BALB/c contain cells with diverse V delta6(D)J delta junctions together with cells with relatively homogeneous V delta6(D)J delta junctions, similar to those found in DBA/2. Thus, the Thy-1(dull) gamma deltapopulation appears to contain two subsets of cells which differ in the diversity of their TCR.

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Documento generato il 04/04/20 alle ore 12:30:55