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Titolo:
Risperidone-induced cholestatic hepatitis
Autore:
Krebs, S; Dormann, H; Muth-Selbach, U; Hahn, EG; Brune, K; Schneider, HT;
Indirizzi:
Univ Erlangen Nurnberg, Inst Expt & Klin Pharmakol & Toxikol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 67 - 69
SICI:
0954-691X(200101)13:1<67:RCH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEPATOTOXICITY;
Keywords:
adverse drug reaction; anti-psychotic drug; hepatotoxicity; neuroleptic; olanzapine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Krebs, S Univ Erlangen Nurnberg, Inst Expt & Klin Pharmakol & Toxikol, Fahrstr 17, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Fahrstr 17 Erlangen Germany D-91054 rmany
Citazione:
S. Krebs et al., "Risperidone-induced cholestatic hepatitis", EUR J GASTR, 13(1), 2001, pp. 67-69

Abstract

Risperidone, a widely used atypical and potent neuroleptic drug, is assumed to induce fewer hepatic side-effects than phenothiazine anti-psychotics. Recently, we observed a case of risperidone-induced cholestatic hepatotoxicity, A 37-year-old male developed a rapid increase in liver enzymes and cholestatic parameters after starting treatment with risperidone for paranoid psychosis, Workup for other potential aetiologies was negative. The resultsof a percutaneous liver biopsy were consistent with drug-induced liver injury and cholestasis. Over the course of one month after the discontinuance of all anti-psychotic agents, the liver function test results returned to near-normal values. This observation supports the need to monitor cholestatic parameters in addition to liver function enzymes during initiation and the first weeks of risperidone intake, Eur J Gastroenterol Hepatol 13:67-69 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:05:47