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Titolo:
Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man
Autore:
Felley, CP; Corthesy-Theulaz, I; Rivero, JLB; Sipponen, P; Kaufmann, M; Bauerfeind, P; Wiesel, PH; Brassart, D; Pfeifer, A; Blum, AL; Michetti, P;
Indirizzi:
Univ Lausanne Hosp, Div Gastroenterol, Lausanne, Switzerland Univ LausanneHosp Lausanne Switzerland oenterol, Lausanne, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 25 - 29
SICI:
0954-691X(200101)13:1<25:FEOAAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACTIC-ACID BACTERIA; REFLUX ESOPHAGITIS; IN-VITRO; INFECTION; STRAIN; CLARITHROMYCIN; COLONIZATION; ERADICATION; EXPRESSION; SURVIVAL;
Keywords:
bacterial interference; Helicobacter pylori; Lactobacillus johnsonii;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Michetti, P Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, DA-601,330 Brookline Ave, Boston, MA 02215 USA Harvard Univ DA-601,330 Brookline Ave Boston MA USA 02215 USA
Citazione:
C.P. Felley et al., "Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man", EUR J GASTR, 13(1), 2001, pp. 25-29

Abstract

Objective The supernatant of Lactobacillus johnsonii La1 culture was shownto be bactericidal and to have a partial, acid-independent suppressive effect on Helicobacter pylori in humans. The aim of the present study was to investigate the effect of L. johnsonii La1-acidified milk (LC-1) on H. pylori infection,Design and methods Fifty-three volunteers infected with H. pylori as determined by positive C-13-urea breath test and positive serology were randomized to receive either LC-1 or a placebo 180 mi twice a day for 3 weeks. All subjects also received clarithromycin 500 mg bid during the last two weeks of acidified milk therapy. Oesophagogastroduodenoscopy and biopsies were performed at inclusion and repeated 4-8 weeks after the end of the treatment,H. pylori infection was confirmed by urease test and histology, H. pylori density and inflammation were scored using a modified Sydney classification. Results LC-1 ingestion induced a decrease in H. pylori density in the antrum (P = 0.02) and the corpus (P = 0.04). LC-1 also reduced inflammation andgastritis activity in the antrum (P = 0.02 and P = 0.01, respectively) andof activity in the corpus (P = 0.02), Clarithromycin eradicated H. pylori in 26% of the subjects; LC-I did not improve the antibiotic effect. Conclusion These results suggest that H. pylori infection and gastritis can be down-regulated by LC-I. Eur J Gastroenterol Hepatol 13:25-29 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:18:26