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Titolo:
Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol-induced seizures
Autore:
Erakovic, V; Zupan, G; Varljen, J; Laginja, J; Simonic, A;
Indirizzi:
Univ Rijeka, Sch Med, Dept Pharmacol, Rijeka, Croatia Univ Rijeka RijekaCroatia ka, Sch Med, Dept Pharmacol, Rijeka, Croatia Univ Rijeka, Sch Med, Dept Chem & Biochem, Rijeka, Croatia Univ Rijeka Rijeka Croatia ch Med, Dept Chem & Biochem, Rijeka, Croatia
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 43, anno: 2001,
pagine: 165 - 173
SICI:
0920-1211(200102)43:2<165:AAORBM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE; GLUTAMATE BINDING; NMR-SPECTROSCOPY; HIPPOCAMPUS; NALOXONE; SERUM;
Keywords:
alkaline phosphatase; creatine kinase; glutamate dehydrogenase; gamma-glulamyltransferase; lactate dehydrogenase; pentylenetetrazol kindling; rats; transaminases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Erakovic, V PLIVA R&D, Prilaz Baruna Filipovica 25, HR-10000 Zagreb, Croatia PLIVA R&D Prilaz Baruna Filipovica 25 Zagreb Croatia HR-10000
Citazione:
V. Erakovic et al., "Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol-induced seizures", EPILEPSY R, 43(2), 2001, pp. 165-173

Abstract

The aim of our study was to investigate amino acid and energy metabolism of pentylenetetrazol (PTZ)-kindled animals. Glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine-aminotransferase, gamma -glutamyltransferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were determined in the frontal cortex, cerebellum hippocampus and pons-medulla regions of Hannover-Wistar rats. The rats were randomly divided into four experimental groups: (a) control; (b) rats which received a single PTZ injection in a subconvulsive dose of 40 mg/kg i.p.; (c) rats which received a single PTZ injection in a convulsive dose of 50 mg/kg i.p.; and (d) PTZ-kindled rats. Kindling increased ALP activity throughout the brain, elevated AST as well as LDH activity in the frontal cortex and hippocampus and decreased CK activity in the frontal cortex and cerebellum. Acute seizures of the same intensity did not induce these alterations. The observed effects therefore are obviously linked to the kindling phenomenon and notto seizure activity. Changes appeared mainly in the frontal cortex and hippocampus, i.e. brain areas believed to be directly involved in kindling. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:45:37