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Titolo:
Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection
Autore:
Engstrom, ER; Hillered, L; Flink, R; Kihlstrom, L; Lindquist, C; Nie, JX; Olsson, Y; Silander, HC;
Indirizzi:
Univ Uppsala Hosp, Dept Neurosurg, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 rosurg, S-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Clin Neurophysiol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 hysiol, S-75185 Uppsala, Sweden Karolinska Hosp Stockholm, Dept Neurosurg, Stockholm, Sweden Karolinska Hosp Stockholm Stockholm Sweden Neurosurg, Stockholm, Sweden Univ Uppsala Hosp, Dept Genet & Pathol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 Pathol, S-75185 Uppsala, Sweden
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2, volume: 43, anno: 2001,
pagine: 135 - 144
SICI:
0920-1211(200102)43:2<135:EAALMW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPILEPTIFORM DISCHARGES; GLUTAMATE TRANSPORTERS; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; BRAIN INJURY; RAT-BRAIN; SEIZURES; CORTEX; FOCI; HIPPOCAMPUS;
Keywords:
posttraumatic epilepsy; amino acids; iron chloride; animal model; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Engstrom, ER Univ Uppsala Hosp, Dept Neurosurg, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 85 Uppsala, Sweden
Citazione:
E.R. Engstrom et al., "Extracellular amino acid levels measured with intracerebral microdialysis in the model of posttraumatic epilepsy induced by intracortical iron injection", EPILEPSY R, 43(2), 2001, pp. 135-144

Abstract

An iron induced model of posttraumatic chronic focal epilepsy in rats was studied with respect to extracellular amino acids, electrophysiology, and morphology, approx. 6 months after intracortical injection of ferrous chloride. Twenty-six of the twenty-eight (93%) rats developed spontaneous epileptiform EEG-activity and electrical cortical stimulation done in eight animals evoked seizure activity in five animals (62.5%). Epileptic brain tissue displayed significantly higher extracellular interictal levels of aspartate (ASP), compared to normal brain, measured with intracerebral microdialysis. The interictal levels of serine (SER) were significantly higher at the lesion side compared to the contralateral cortex in epileptic animals. Spontaneous elevations of ASP and glutamate (GLU) levels up to 8 times the basal level were found in 4/5 (80%). There was no consistent amino acid pattern following the electrically induced seizures, but in association with more intense seizure activity ASP and GLU were elevated. Histopathologically, the necrotic lesions in the cortex contained small vessels and iron pigment loaded astrocytes. Scattered eosinophilic neurons were found in the hippocampus, bilaterally in 37% of the animals. The results show that a focal epileptiform activity developed in a high percentage of animals that received an intracortical iron injection. The observed amino acid changes in epileptic animals may be involved in the development of seizures in this model of posttraumatic epilepsy. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 29/03/20 alle ore 07:44:42