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Titolo:
A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network
Autore:
Liu, SH; Towler, MC; Chen, E; Chen, CY; Song, WX; Apodaca, G; Brodsky, FM;
Indirizzi:
Univ Calif San Francisco, GW Hooper Fdn, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA Univ Maryland College Pk MD USA 20742 Cell Biol, College Pk, MD 20742 USA Univ Pittsburgh, Dept Med, Div Renal Electrolyte, Pittsburgh, PA 15261 USAUniv Pittsburgh Pittsburgh PA USA 15261 trolyte, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Physiol, Pittsburgh, PA 15261 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 1-2, volume: 20, anno: 2001,
pagine: 272 - 284
SICI:
0261-4189(20010115)20:1-2<272:ANCHTC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AP-3 ADAPTER COMPLEX; HEAVY-CHAIN GENE; PROTEIN COMPLEX; CHROMOSOME 22Q11; CELL-SURFACE; MYOSIN-II; MEMBRANE; VESICLES; TEMPERATURE; REGION;
Keywords:
clathrin; cytoskeleton; homolog; muscle; trans-Golgi network;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Brodsky, FM Univ Calif San Francisco, GW Hooper Fdn, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CAUSA 94143 94143 USA
Citazione:
S.H. Liu et al., "A novel clathrin homolog that co-distributes with cytoskeletal components functions in the trans-Golgi network", EMBO J, 20(1-2), 2001, pp. 272-284

Abstract

A clathrin homolog encoded on human chromosome 22 (CHC22) displays distinct biochemistry, distribution and function compared with conventional clathrin heavy chain (CHC17), encoded on chromosome 17, CHC22 protein is upregulated during myoblast differentiation into myotubes and is expressed at high levels in muscle and at low levels in non-muscle cells, relative to CHC17, The trimeric CHC22 protein does not interact with clathrin heavy chain subunits nor bind significantly to clathrin light chains. CHC22 associates withthe AP1 and AP3 adaptor complexes but not with AP2, In non-muscle tells, CHC22 localizes to perinuclear vesicular structures, the majority of which are not clathrin coated, Treatments that disrupt the actin-myosin cytoskeleton or affect sorting in the trans-Golgi network (TGN) cause CHC22 redistribution. Overexpression of a subdomain of CHC22 induces altered distribution of TGN markers. Together these results implicate CHC22 in TGN membrane traffic involving the cytoskeleton.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:13:44