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Titolo:
Actin dynamics and cell-cell adhesion in epithelia
Autore:
Vasioukhin, V; Fuchs, E;
Indirizzi:
Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol, Chicago,IL 60637 USA Univ Chicago Chicago IL USA 60637 Genet & Cell Biol, Chicago,IL 60637 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 76 - 84
SICI:
0955-0674(200102)13:1<76:ADACAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAENORHABDITIS-ELEGANS EMBRYO; ALPHA-CATENIN; E-CADHERIN; BETA-CATENIN; LISTERIA-MONOCYTOGENES; CYTOPLASMIC DOMAIN; MDCK CELLS; MYOSIN-II; F-ACTIN; PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, E Univ Chicago, Howard Hughes Med Inst, Dept Mol Genet & Cell Biol,5841 S Maryland Ave,Room N314, Chicago, IL 60637 USA Univ Chicago 5841 S Maryland Ave,Room N314 Chicago IL USA 60637 A
Citazione:
V. Vasioukhin e E. Fuchs, "Actin dynamics and cell-cell adhesion in epithelia", CURR OP CEL, 13(1), 2001, pp. 76-84

Abstract

Recent advances in the field of intercellular adhesion highlight the importance of adherens junction association with the underlying actin cytoskeleton. In skin epithelial cells a dynamic feature of adherens junction formation involves filopodia, which physically project into the membrane of adjacent cells, catalyzing the clustering of adherens junction protein complexes at their tips. In turn, actin polymerization is stimulated at the cytoplasmic interface of these complexes. Although the mechanism remains unclear, the VASP/Mena family of proteins seems to be involved in organizing actin polymerization at these sites. In vivo, adherens junction formation appears torely upon filopodia in processes where epithelial sheets must be physically moved closer to form stable intercellular connections, for example, in ventral closure in embryonic development or wound healing in the postnatal animal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:18:05