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Titolo:
Effect of AVT antisense oligodeoxynucleotides on AVT release induced by hypertonic stimulation in chicks
Autore:
Saito, N; Sasaki, T; Furuse, M; Arakawa, K; Shimada, K;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Physiol Anim Lab, Nagoya, Aichi 4648601,Japan Nagoya Univ Nagoya Aichi Japan 4648601 m Lab, Nagoya, Aichi 4648601,Japan Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Feed Sci, Fukuoka8128581, Japan Kyushu Univ Fukuoka Japan 8128581 i, Lab Feed Sci, Fukuoka8128581, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 147 - 153
SICI:
1095-6433(200101)128:1<147:EOAAOO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER-DEPRIVED CHICKENS; ARGININE VASOTOCIN; GENE-EXPRESSION; MESSENGER-RNA; PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES; REPRODUCTIVE-BEHAVIOR; PLASMA OSMOLALITY; GALLUS-DOMESTICUS; FEMALE RAT; LAYING HEN;
Keywords:
antisense oligodeoxynucleotide (ODN); osmotic stimulus; neurohypophyseal hormones; chick; arginine vasotocin; radioimmunoassay; cerebral ventricle; mesotocin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Saito, N Nagoya Univ, Grad Sch Bioagr Sci, Physiol Anim Lab, Nagoya, Aichi4648601,Japan Nagoya Univ Nagoya Aichi Japan 4648601 goya, Aichi 4648601,Japan
Citazione:
N. Saito et al., "Effect of AVT antisense oligodeoxynucleotides on AVT release induced by hypertonic stimulation in chicks", COMP BIOC A, 128(1), 2001, pp. 147-153

Abstract

In birds, arginine vasotocin (AVT) and mesotocin (MT) are the neurohypophyseal hormones. AVT is known to be an avian antidiuretic hormone and is released from the neurohypophysis by dehydration or hyperosmotic stimulation. The purpose of this study was to determine whether the mechanism of AVT synthesis is related to the mechanism of hormone release from the neurohypophysis. Four-day-old chicks received an AVT antisense oligodeoxynucleotide (ODN) injection into the cerebral ventricle (icv). Following antisense administration, the chicks received hypertonic saline stimulation. Plasma levels ofAVT and MT were measured by radioimmunoassays. In control birds, a hypertonic saline injection resulted in the increase of plasma AVT level. The administration of a high dose (50 mug) of antisense ODN inhibited the increase of plasma AVT level induced by the hypertonic saline stimulation. Plasma levels of MT did not change with the administration of hypertonic saline or antisense ODN. These results suggest that the mechanisms that regulate the secretion of AVT from the neurohypophysis may be coupled to the mechanisms that regulate the synthesis of AVT. (C) 2001 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:26:18