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Titolo:
WOMEN WITH INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) COMPLICATED BY EATING DISORDERS ARE AT RISK FOR EXACERBATED ALTERATIONS IN LIPID-METABOLISM
Autore:
AFFENITO SG; LAMMIKEEFE CJ; VOGEL S; BACKSTRAND JR; WELCH GW; ADAMS CH;
Indirizzi:
UNIV CONNECTICUT,SCH ALLIED HLTH STORRS CT 06269 UNIV CONNECTICUT,DEPT NUTR SCI STORRS CT 06269 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BOSTON MA 02215 HARVARD UNIV,SCH MED,JOSLIN DIABET CTR,MENTAL HLTH UNIT BOSTON MA 02215
Titolo Testata:
European journal of clinical nutrition
fascicolo: 7, volume: 51, anno: 1997,
pagine: 462 - 466
SICI:
0954-3007(1997)51:7<462:WWID(C>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANOREXIA-NERVOSA; BULIMIA-NERVOSA; MICRONUTRIENT; BINDING; VITAMIN; SERUM;
Keywords:
LIPID METABOLISM, ALPHA-TOCOPHEROL; CAROTENOID; GLYCOSYLATED HEMOGLOBIN; INSULIN-DEPENDENT DIABETES MELLITUS; EATING DISORDERS; BULIMIA NERVOSA; ANOREXIA NERVOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.G. Affenito et al., "WOMEN WITH INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) COMPLICATED BY EATING DISORDERS ARE AT RISK FOR EXACERBATED ALTERATIONS IN LIPID-METABOLISM", European journal of clinical nutrition, 51(7), 1997, pp. 462-466

Abstract

Objective: To examine lipid parameters that are affected in women with insulin-dependent diabetes mellitus (IDDM) who engaged in disorderedeating behaviours. Design: Randomized, unmatched. Setting: Tertiary care. Subjects: Ninety women (18-46 y) with IDDM. Interventions: Classification of subjects based on severity of eating disorder: clinical (n=14), subclinical (n=13) and control (n=63). Blood was analysed for glycosylated haemoglobin (HbA(1c)) and serum for triglycerides and cholesterol. Carotenoid and tocopherol concentrations were analysed by highperformance liquid chromatography (HPLC). Dietary intake was assessedby the National Cancer Institute food frequency questionnaire. Results: HbA(1c) was significantly increased im women demonstrating clinicaland subclinical symptoms compared to control (10.4+/-2.6, 10.0+/-1.5 and 8.3+/-1.6%, respectively, P<0.05). Triglyceride concentrations were significantly increased in women with subclinical eating disorders compared to controls. In women who intentionally omitted or reduced insulin, triglyceride cholesterol and HbA(1c) were significantly increased compared to controls. Women with IDDM and eating disorders who exhibited bulimic behaviours consumed significantly more energy, total fat and cholesterol compared to controls and women with eating disorders who were restrained eaters. Conclusion: While IDDM is known to perturb lipid metabolism, these data demonstrate that eating disorders, in combination with IDDM, results in additional alterations in lipid metabolism.

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Documento generato il 27/11/20 alle ore 02:01:40