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Titolo:
Angiotensin receptor(s) in fowl
Autore:
Kempf, H; Corvol, P;
Indirizzi:
INSERM, U36, F-75005 Paris, France INSERM Paris France F-75005INSERM, U36, F-75005 Paris, France Coll France, F-75005 Paris, France Coll France Paris France F-75005Coll France, F-75005 Paris, France
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 77 - 88
SICI:
1095-6433(200101)128:1<77:ARIF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
II-BINDING-SITES; MOLECULAR-CLONING; CHORIOALLANTOIC MEMBRANE; MEDIATED STIMULATION; ADRENAL-GLAND; MESSENGER-RNA; CHICK-EMBRYO; EXPRESSION; ANGIOGENESIS; VASOPRESSOR;
Keywords:
angiotensin II receptor; AT(1); AT(2); losartan; endothelium; expression pattern; embryo; chicken; fowl; Gallus gallus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Kempf, H Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Laser Lab,240 Longwood Ave, Boston, MA 02115 USA Harvard Univ 240 Longwood Ave Boston MA USA 02115 n, MA 02115 USA
Citazione:
H. Kempf e P. Corvol, "Angiotensin receptor(s) in fowl", COMP BIOC A, 128(1), 2001, pp. 77-88

Abstract

The cloning of the avian Ang II receptor shows that it is molecularly close to the AT(1)-type mammalian receptor. However, pharmacological characterization in transfected cells shows that, even though the avian receptor is coupled to the phospholipase C, as is the AT(1), its profile of specificity towards antagonists appears different from that of the two angiotensin II mammalian receptor types. The fowl Ang II receptor mRNA is expressed in classical adult target organs for Ang II and, interestingly, also in endothelial cells, but not in vascular smooth muscle cells. In the endothelial cells,it may mediate the peculiar vasorelaxation effect of Ang II already reported in the chicken. The recent description of the expression pattern in the chick embryo shows that the avian Ang II receptor is expressed in many different mesenchymal tissues, a feature which is the signature of the AT(2) mammalian receptor. Altogether, these data imply that the avian Ang II receptor is an atypical receptor that cannot be readily classified as either of the two mammalian Ang II receptor types and, therefore, reinforce the evidence for another Ang II receptor in the avian class. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:35:34