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Titolo:
Comparative analysis of amphibian and mammalian angiotensin receptors
Autore:
Sandberg, K; Ji, H;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ept Med, Washington, DC 20007 USA Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20007 USAGeorgetown Univ Washington DC USA 20007 Biophys, Washington, DC 20007 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 53 - 75
SICI:
1095-6433(200101)128:1<53:CAOAAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
II-BINDING-SITES; PROTEIN-COUPLED RECEPTORS; AGONIST-INDUCED INTERNALIZATION; BULLFROG RANA-CATESBEIANA; WATER-ABSORPTION RESPONSE; ATRIAL-NATRIURETIC-FACTOR; XENOPUS-LAEVIS OOCYTES; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID-RESIDUES; SMOOTH-MUSCLE CELLS;
Keywords:
angiotensin; AT(1) receptor; xAT receptor; amphibian; signal transduction or signaling; G protein-coupled receptor (GPCR); ligand binding (peptide and non-peptide); internalization; post transcriptional regulation (3 ' untranslated region and 5 ' untranslated region); structure/function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
162
Recensione:
Indirizzi per estratti:
Indirizzo: Sandberg, K 394 Bldg D,4000 Reservoir Rd NW, Washington, DC 20007 USA 394Bldg D,4000 Reservoir Rd NW Washington DC USA 20007 7 USA
Citazione:
K. Sandberg e H. Ji, "Comparative analysis of amphibian and mammalian angiotensin receptors", COMP BIOC A, 128(1), 2001, pp. 53-75

Abstract

Amphibian angiotensin receptors (xAT receptors) share many similarities with mammalian type 1 angiotensin receptors (AT(1) receptors). Both xAT and AT(1) receptors belong to the super family of seven transmembrane spanning Gprotein-coupled receptors and share approximately 60% amino acid homology. Highly stable secondary structure in the 5' leader sequences and the presence of the mRNA destabilizing sequence (AUUUA) in the 3' untranslated region (3'UTR) of the xAT and AT(1) receptor mRNAs suggest similar mechanisms exist for regulating gene expression. Amphibian and mammalian AT receptors bind angiotensin with equivalent affinities but show marked differences in their affinities towards mammalian AT(1) receptor subtype selective non-peptide ligands. Both xAT and AT(1) receptors couple to G proteins and to the phospholipase C (PLC) signal transduction pathway. Mammalian AT(1) receptors play a key role in maintaining blood pressure and fluid homeostasis and there is considerable evidence that xAT receptors play a similarly important role in amphibians. This review focuses on the comparison of amphibian xAT receptors with mammalian AT(1) receptors in terms of their structure, pharmacology, signaling, and function. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:05:56