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Titolo:
Angiotensin receptors - evolutionary overview and perspectives
Autore:
Nishimura, H;
Indirizzi:
Univ Tennessee, Ctr Hlth Sci, Dept Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Dept Physiol, Memphis, TN 38163 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 11 - 30
SICI:
1095-6433(200101)128:1<11:AR-EOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; VASCULAR SMOOTH-MUSCLE; TYPE-2 AT(2) RECEPTOR; XENOPUS-LAEVIS HEART; II BINDING-SITES; MOLECULAR-CLONING; SIGNAL-TRANSDUCTION; CHEMICAL-STRUCTURE; CARDIOVASCULAR-SYSTEM; ONCORHYNCHUS-MYKISS;
Keywords:
angiotensin receptor; renin-angiotensin system; AT(1) receptor; AT(2) receptor; native angiotensin; receptor modulation; evolution; non-mammalian angiotensin; signalling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Nishimura, H Univ Tennessee, Ctr Hlth Sci, Dept Physiol, 894 Union Ave, Memphis, TN 38163 USA Univ Tennessee 894 Union Ave Memphis TN USA 38163 N 38163 USA
Citazione:
H. Nishimura, "Angiotensin receptors - evolutionary overview and perspectives", COMP BIOC A, 128(1), 2001, pp. 11-30

Abstract

The structure of the angiotensin molecule has been well preserved throughout the vertebrate scale with some amino acid variations. Specific angiotensin receptors (AT receptors) that mediate important physiological functions have been noted in a variety of tissues and species. Physiological and pharmacological characterization of AT receptors and, more recently, molecular cloning studies have elucidated the presence of AT receptor subtypes. Comparative studies suggest that an AT receptor subtype homologous to the mammalian type 1 receptor subtype (AT(1)), though pharmacologically distinct, is present in amphibians and birds, whereas AT receptors cloned from teleosts show low homology to both AT(1) and AT(2) receptor subtypes. Furthermore, receptors differing from both the AT(1)-homologue receptor and AT(2) receptor exist in some non-mammalian species. This may suggest that the prototype AT receptor evolved in primitive vertebrates and diverged to more than one type of AT receptor subtype during phylogeny. Furthermore, phenotypic modulation of AT receptors appears to occur during individual development/maturation. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:11:15