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Titolo:
Increased fatty acid synthase is a therapeutic target in mesothelioma
Autore:
Gabrielson, EW; Pinn, ML; Testa, JR; Kuhajda, FP;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 Pathol, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 Oncol, Baltimore, MD 21224 USA Fox Chase Canc Ctr, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 1, volume: 7, anno: 2001,
pagine: 153 - 157
SICI:
1078-0432(200101)7:1<153:IFASIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLEURAL MESOTHELIOMA; BREAST-CANCER; EXPRESSION; INHIBITION; MODEL; SYNTHETASE; CARCINOMA; CERULENIN; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhajda, FP Johns Hopkins Bayview Med Ctr, Bldg A,Room 154A,4940 Eastern Ave, Baltimore, MD 21224 USA Johns Hopkins Bayview Med Ctr Bldg A,Room 154A,4940 Eastern Ave Baltimore MD USA 21224
Citazione:
E.W. Gabrielson et al., "Increased fatty acid synthase is a therapeutic target in mesothelioma", CLIN CANC R, 7(1), 2001, pp. 153-157

Abstract

Many common human cancer tissues express high levels of fatty acid synthase (FAS), the primary enzyme for the synthesis of fatty acids, and the differential expression of FAS between normal and neoplastic tissues has led to the consideration of FAS as a target for anticancer therapy, To investigatethe potential of targeting FAS for the treatment of pleural mesothelioma, we first determined whether FAS is overexpressed in human mesothelioma. By immunohistochemistry, we found 22 of 30 human mesothelioma tissue samples tested to express significantly increased levels of FAS compared with normaltissues, including mesothelium, To further explore FAS as a therapeutic target in mesothelioma, we established a nude mouse xenograft model for humanmesothelioma using the H-Meso cell line. The i.p. xenografts of this cell line have high levels of FAS expression and fatty acid synthesis pathway activity and grow along mesothelial surfaces in a manner similar to the growth pattern of human mesothelioma. Growth of these tumor xenografts was essentially abolished in mice treated with weekly i.p. injections of C75, a synthetic, small molecule inhibitor of FAS, at levels that resulted in no significant systemic toxicity except for reversible weight loss. These results suggest that FAS may be an effective target for pharmacological therapy in ahigh proportion of human mesotheliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:29:38