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Titolo:
Myocardial fibrosis in DOCA-salt hypertensive rats - Effect of endothelin ETA receptor antagonism
Autore:
Ammarguellat, F; Larouche, I; Schiffrin, EL;
Indirizzi:
Clin Res Inst Montreal, Multidisciplinary Res Grp Hypertens, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal Montreal PQ Canada H2W 1R7 eal, PQ H2W 1R7, Canada
Titolo Testata:
CIRCULATION
fascicolo: 2, volume: 103, anno: 2001,
pagine: 319 - 324
SICI:
0009-7322(20010116)103:2<319:MFIDHR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEART-FAILURE; BLOOD-PRESSURE; PATHOLOGICAL HYPERTROPHY; VENTRICULAR HYPERTROPHY; ARTERIAL-HYPERTENSION; VASCULAR HYPERTROPHY; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; COLLAGEN GENE; MESSENGER-RNA;
Keywords:
collagen; myocardium; growth substances;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Schiffrin, EL Clin Res Inst Montreal, Multidisciplinary Res Grp Hypertens,110 Ave Pine Ouest, Montreal, PQ H2W 1R7, Canada Clin Res Inst Montreal 110 Ave Pine Ouest Montreal PQ Canada H2W 1R7
Citazione:
F. Ammarguellat et al., "Myocardial fibrosis in DOCA-salt hypertensive rats - Effect of endothelin ETA receptor antagonism", CIRCULATION, 103(2), 2001, pp. 319-324

Abstract

Background-To test the hypothesis that endothelin-l contributes to cardiacfibrosis, cardiac collagen deposition was studied in deoxycorticosterone acetate-salt (DOCA-salt) hypertensive rats, in which the endothelin system is activated. The effects of the ETA-selective endothelin receptor antagonist A-127722 were evaluated. Methods and Results-A-127722 (30 mg/kg per day) was administered for ii weeks. Myocardial fibrosis was evaluated after Sirius red F3BA staining. Systolic blood pressure was 103+/-1.6 mm Hg in unilaterally nephrectomized rats(Uni-Nx), 202+/-3.2 mm Hg in DOCA-salt rats (P<0.01 versus Uni-Nx), and 182+/-3.1 mm Hg in ETA antagonist-treated DOCA-salt rats (P<0.01 versus DOCA-salt or Uni-Nx), In DOCA-salt rats, interstitial and perivascular collagen density was increased in the subendocardial and midmyocardial regions of the left ventricle (3- to 4-fold, P<0.05), whereas in subepicardial myocardium, the increase was predominantly perivascular. The ETA antagonist prevented cardiac fibrosis in DOCA-salt rats. Procollagen I and III mRNA, which were increased in hearts of DOCA-salt rats, were normalized by ETA antagonist treatment. TGF-<beta>(1) mRNA and TCF-beta (1) protein increased at 1 week in DOCA-salt rats and were lowered in ETA antagonist-treated rats. Conclusions-ETA receptor-mediated collagen deposition in hearts of DOCA-salt rats results from increased procollagen synthesis associated with an initial increment in expression of TGF-beta (1). These results support the hypothesis of a role for endothelin-1 in cardiac collagen deposition in mineralocorticoid hypertension, which may have pathophysiological and pharmacological implications in hypertensive heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:43:26