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Titolo:
Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
Autore:
Gullestad, L; Aass, H; Fjeld, JG; Wikeby, L; Andreassen, AK; Ihlen, H; Simonsen, S; Kjekshus, J; Nitter-Hauge, S; Ueland, T; Lien, E; Froland, SS; Aukrust, P;
Indirizzi:
Univ Oslo, Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 n Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Nucl Med Sect, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 ikshosp, Nucl Med Sect, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Internal Med Res Inst, Dept Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Med Res Inst, Dept Med, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo OsloNorway N-0027 shosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Cardiol, N-0027 Oslo, Norway
Titolo Testata:
CIRCULATION
fascicolo: 2, volume: 103, anno: 2001,
pagine: 220 - 225
SICI:
0009-7322(20010116)103:2<220:ITWIII>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; IDIOPATHIC DILATED CARDIOMYOPATHY; IMMUNE GLOBULIN; IN-VIVO; CYTOKINES; MYOCARDITIS; AUTOIMMUNE; RECEPTORS; SYSTEM;
Keywords:
heart failure; inflammation; interleukins; immune system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Univ Oslo, Rikshosp, Dept Med, Sect Clin Immunol & Infect Dis, Sognsvannsveien 20, N-0027 Oslo, Norway Univ Oslo Sognsvannsveien 20 Oslo Norway N-0027 7 Oslo, Norway
Citazione:
L. Gullestad et al., "Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure", CIRCULATION, 103(2), 2001, pp. 220-225

Abstract

Background-Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatoryresponses in CHF patients and have potential beneficial effects on the left ventricular ejection fraction (LVEF). Methods and Results-Forty patients with chronic symptomatic CHF and LVEF of <40%, stratified according to cause (ie, ischemic and idiopathic dilated cardiomyopathy), were randomized in a double blind fashion to receive therapy with IVIG or placebo for a total period of 26 weeks. Our main findings were that (1) IVIG, but not placebo, induced a marked rise in plasma levels of the anti-inflammatory mediators interleukin (IL)-10, IL-1 receptor antagonist, and soluble tumor necrosis factor receptors, (2) significantly correlated with these anti-inflammatory effects, IVIG, but not placebo, induced a significant increase in LVEF from 26+/-2% to 31+/-3% (P<0.01), and this was found independent of the cause of heart failure; and (3) N-terminal pro-atrial natriuretic peptide decreased significantly after induction therapy and : continued to decrease toward the end of study during IVIG therapy (P<0.001) but remained unchanged during placebo. Conclusions-We demonstrated an IVIG-induced change in the balance between inflammatory and anti-inflammatory cytokines that favored an anti-inflammatory net effect in CHF. This effect was significantly correlated with an improvement in LVEF, suggesting a potential for immunomodulating therapy in addition to optimal conventional cardiovascular treatment regimens in CHF patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:44:51