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Titolo:
Determination of silybin in blood plasma using high performance liquid chromatography with solid phase extraction
Autore:
Kosina, P; Bartek, J;
Indirizzi:
Palacky Univ, Ctr Bioanalyt Res, Olomouc 77515, Czech Republic Palacky Univ Olomouc Czech Republic 77515 Olomouc 77515, Czech Republic Palacky Univ, Fac Med, Inst Med Biochem & Chem, Olomouc 77515, Czech Republic Palacky Univ Olomouc Czech Republic 77515 Olomouc 77515, Czech Republic
Titolo Testata:
CHEMICKE LISTY
fascicolo: 12, volume: 94, anno: 2000,
pagine: 1115 - 1117
SICI:
0009-2770(2000)94:12<1115:DOSIBP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
CZE
Soggetto:
SILIBININ DIASTEREOMERS; SILYMARIN; PHARMACOKINETICS; MARIANUM; ASSAY; HPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kosina, P Palacky Univ, Ctr Bioanalyt Res, Hnevotinska 3, Olomouc 77515, Czech Republic Palacky Univ Hnevotinska 3 Olomouc Czech Republic 77515 epublic
Citazione:
P. Kosina e J. Bartek, "Determination of silybin in blood plasma using high performance liquid chromatography with solid phase extraction", CHEM LISTY, 94(12), 2000, pp. 1115-1117

Abstract

HPLC method with SPE preseparation step for determination of silybin, the main constituent of silymarin, in blood plasma was optimized. A C18 sorbentfor preseparation from acidified samples was used. Diastereomers of silybin in unconjugated form or total silybin are resolved by the method, the detection limit being 2 nmol.l(-1) and the limit of quantification 5 nmol.l(-1) per diastereomer. The method is suitable for silybin monitoring in human plasma after administration of drugs or food additives based on silymarin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:28:29