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Titolo:
Parkinsonism in patients with vascular dementia: Clinical, computed- and positron emission-tomographic findings
Autore:
De Reuck, J; Siau, B; Decoo, D; Santens, P; Crevits, L; Strijckmans, K; Lemahieu, I;
Indirizzi:
State Univ Ghent Hosp, Dept Neurol, B-9000 Ghent, Belgium State Univ GhentHosp Ghent Belgium B-9000 Neurol, B-9000 Ghent, Belgium State Univ Ghent, Inst Nucl Sci, Dept Analyt Chem, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 Analyt Chem, B-9000 Ghent, Belgium State Univ Ghent, Dept Elect & Informat Syst, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 format Syst, B-9000 Ghent, Belgium
Titolo Testata:
CEREBROVASCULAR DISEASES
fascicolo: 1, volume: 11, anno: 2001,
pagine: 51 - 58
SICI:
1015-9770(2001)11:1<51:PIPWVD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; BASAL GANGLIA; OXYGEN-METABOLISM; DIFFERENTIAL-DIAGNOSIS; LACUNAR INFARCTS; SENILE DEMENTIA; NORMAL VALUES; LOWER-BODY; DISEASE; PET;
Keywords:
Parkinsonism, vascular; dementia, vascular; striatum; lacunar infarcts; positron emission tomography; cerebral blood flow, regional; oxygen metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: De Reuck, J State Univ Ghent Hosp, Dept Neurol, Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp Pintelaan 185 Ghent Belgium B-9000 gium
Citazione:
J. De Reuck et al., "Parkinsonism in patients with vascular dementia: Clinical, computed- and positron emission-tomographic findings", CEREB DIS, 11(1), 2001, pp. 51-58

Abstract

Purpose: The present study investigates the vascular nature of parkinsonian features in patients with 'probable' vascular dementia. Patients and Methods: Forty patients with vascular dementia were studied with positron emission tomography (PET) using the steady state technique with O-15 in order toassess regional cerebral blood flow (rCBF), regional oxygen extraction rate (rOER) and regional metabolic rate for oxygen (rCMRO(2)) in different brain regions. The findings in 10 patients with (VaDP) were compared to 30 without parkinsonism (VaD). Results: The clinical and computed tomographic findings in the parkinsonian patients were similar to those described in the literature as probable vascular parkinsonism. The PET results showed decreased rCBF and rCMRO(2) in the frontal and parietal cortices and in the striatum of the VaDP compared to the VaD group. The decrease of rCBF and rCMRO(2)in frontal and parietal cortices is due to the more severe mental changes in the VaDP group. In the VaDP patients rCBF and rCMRO(2) were more decreased and rOER increased in the striatum contralateral to the most affected parkinsonian side. Conclusion: Our PET findings show that local ischemic changes in the striatum contribute to parkinsonism in vascular dementia patients. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 17/09/19 alle ore 23:11:42