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Titolo:
Altered regulation of the myocardial microcirculation in young smokers
Autore:
Madsen, MM; Bottcher, M; Nielsen, TT; Czernin, J;
Indirizzi:
Aarhus Univ Hosp, Dept Cardiol B, SKS, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N diol B, SKS, DK-8200 Aarhus N, Denmark Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Div Nucl Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA Nucl Med, Los Angeles, CA USA Univ Calif Los Angeles, Lab Struct Biol & Mol Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA & Mol Med, Los Angeles, CA USA
Titolo Testata:
CARDIOLOGY
fascicolo: 2, volume: 94, anno: 2000,
pagine: 91 - 98
SICI:
0008-6312(2000)94:2<91:AROTMM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; POSITRON EMISSION TOMOGRAPHY; ENDOTHELIUM-DEPENDENT DILATION; CARDIAC PET IMAGES; LONG-TERM SMOKING; BLOOD-FLOW; RISK-FACTORS; CIGARETTE-SMOKING; N-13 AMMONIA; ATHEROSCLEROSIS;
Keywords:
smoking; myocardial blood flow; positron emission tomography; endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bottcher, M Aarhus Univ Hosp, Dept Cardiol B, SKS, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N DK-8200 Aarhus N, Denmark
Citazione:
M.M. Madsen et al., "Altered regulation of the myocardial microcirculation in young smokers", CARDIOLOGY, 94(2), 2000, pp. 91-98

Abstract

Smoking is known to affect microcirculatory function in a middle-aged population, However, the effects of smoking on myocardial perfusion in young smokers have not been studied. Myocardial perfusion was measured in 15 smokers (24 +/- 2 years) and 15 nonsmokers (24 +/- 3 years) using positron emission tomography. Myocardial perfusion was measured at rest, during cold stress and during dipyridamole. Re!;ting myocardial blood flow was similar in the two groups. The well-described correlation between rate-pressure product and myocardial blood flow was present only in the nonsmokers (r(2) = 0.61, p < 0.001), Myocardial blood flow corrected for the rate-pressure product declined during cold by 20% in the smokers [1.11 +/- 0.28 vs. 0.92 +/- 0.20 ml.g(-1) min(-1) (p = 0.012)], but remained unchanged in nonsmokers [1.11 +/- 0.25 vs. 1.09 +/- 0.30 ml g(-1) min(-1) (p = NS)]. Dipyridamole-induced hyperemia was similar in the two groups [2.23 +/- 0.78 vs. 2.42 +/- 0.65 mlg(-1) min(-1) (p = NS)], In conclusion, smoking induces abnormalities in myocardial microcirculatory regulation in young otherwise healthy smokers. The coronary flow reserve, however, is not significantly altered. Copyright (C) 2001 S. Karger AG, Basal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:28:47