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Titolo:
Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21
Autore:
Streubel, B; Valent, P; Lechner, K; Fonatsch, C;
Indirizzi:
Univ Vienna, Inst Med Biol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Inst Med Biol, A-1090 Vienna, Austria Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria
Titolo Testata:
CANCER GENETICS AND CYTOGENETICS
fascicolo: 1, volume: 124, anno: 2001,
pagine: 42 - 46
SICI:
0165-4608(20010101)124:1<42:AOTAGO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; MYELODYSPLASTIC SYNDROME; MYELOGENOUS LEUKEMIA; RIBOSOMAL-RNA; FUSION; AML1; TRANSLOCATIONS; HYBRIDIZATION; ABNORMALITIES; MALIGNANCIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Fonatsch, C Univ Vienna, Inst Med Biol, Wahringer Str 10, A-1090 Vienna, Austria Univ Vienna Wahringer Str 10 Vienna Austria A-1090 a, Austria
Citazione:
B. Streubel et al., "Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21", CANC GENET, 124(1), 2001, pp. 42-46

Abstract

In the genesis of hematologic neoplasms gene amplification is a mechanism for illegitimate activation of proto-oncogenes. We report a phenotypically normal patient with a constitutional ring chromosome 21 who developed acutemyeloid leukemia (BML). The leukemic cells revealed size-variable ring chromosomes 21 with amplification of the proto-oncogene AML1, located in the chromosomal band 21q22. within the rings. Hitherto, amplification of the proto-oncogene AM1-also in form of a ring chromosome-has been described recently only in one patient with myelodysplastic syndrome (MDS). In AML, gene amplification by ring formation has been demonstrated only in another three patients (amplification of the MLL gene in two cases and of the ETV6 gene inone case). Here we present the new evidence that the internal rearrangement of a constitutional ring chromosome 21 resulted in multiplication of a proto-oncogene in bone marrow cells and provided obviously a selective growthadvantage. Moreover the amplification of ribosomal DNA was observed in thering chromosomes of the tumor cells. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:30:57