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Titolo:
Prophylactic efficacy of a new gentamicin-releasing urethral catheter in short-term catheterized rabbits
Autore:
Cho, YH; Lee, SJ; Lee, JY; Kim, SW; Kwon, IC; Chung, SY; Yoon, MS;
Indirizzi:
Korea Inst Sci & Technol, Seoul 130650, South Korea Korea Inst Sci & Technol Seoul South Korea 130650 ul 130650, South Korea Catholic Univ, Coll Med, Dept Urol, Seoul, South Korea Catholic Univ Seoul South Korea Coll Med, Dept Urol, Seoul, South Korea
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 87, anno: 2001,
pagine: 104 - 109
SICI:
1464-4096(200101)87:1<104:PEOANG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-TRACT INFECTIONS; PSEUDOMONAS-AERUGINOSA; FOLEY CATHETER; BACTERIURIA; PREVENTION; PATHOGENESIS; SURFACES; TRIAL;
Keywords:
catheter-associated urinary tract infection; gentamicin; urethral catheter; bacterial biofilm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, SW St Marys Hosp, Dept Urol, 62 Youido Dong, Seoul 150713, South Korea St Marys Hosp 62 Youido Dong Seoul South Korea 150713 South Korea
Citazione:
Y.H. Cho et al., "Prophylactic efficacy of a new gentamicin-releasing urethral catheter in short-term catheterized rabbits", BJU INT, 87(1), 2001, pp. 104-109

Abstract

Objective To describe an indwelling urethral catheter coated with gentamicin sulphate on the inner and outer surface of the catheter, and to evaluatethe efficacy and safety of this catheter in preventing catheter-associatedinfections in rabbits. Materials and methods Sixty rabbits were divided equally into control and experimental groups which were then subdivided equally according to the duration of catheterization (1, 3 and 5 days). Silicone-treated latex catheters were used in the control group and gentamicin-releasing catheters in the experimental group. Urine samples and surface swabs from the catheter were cultured for bacteriological assessment, and the catheter surface examined by scanning electron microscopy to structurally analyse the biofilms. Results The gentamicin-releasing catheter reduced the incidence of bacteriuria (defined as greater than or equal to 100 c.f.u./mL) after both 3 and 5days of catheterization (eight and 10 rabbits, respectively, for the control catheter, vs two and four rabbits for the gentamicin-releasing catheter,P < 0.05). The surfaces of the gentamicin-releasing catheter were colonized less often than those of the control catheter after both 3 and 5 days (eight and 10, respectively, for the control, vs one and four for the gentamicin-releasing catheter, P < 0.05). Scanning electron microscopy showed the formation of bacterial biofilm throughout the 3-day and 5-day control catheters, but deterioration of the bacterial biofilm was visible on the surface of the gentamicin-releasing catheters,Conclusion This new gentamicin-releasing catheter produced an antibacterial barrier which inhibited catheter-associated urinary tract infection with no toxicity for at: least 5 days. These in vivo studies suggest that this new catheter may be useful for controlling infection, with systemic and local safety, in patients undergoing short-term indwelling urethral catheterization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:50:00